Concepedia

A Novel Organometallic Aqua Complex of Technetium for the Labeling of Biomolecules:  Synthesis of [<sup>99m</sup>Tc(OH<sub>2</sub>)<sub>3</sub>(CO)<sub>3</sub>]<sup>+</sup> from [<sup>99m</sup>TcO<sub>4</sub>]<sup>-</sup> in Aqueous Solution and Its Reaction with a Bifunctional Ligand

Roger Alberto, Roger Schibli, André Egli, August P. Schubiger, Ulrich Abram, Thomas A. Kaden

Journal of the American Chemical Society · 1998 · 665 citations · 10 references

DOI

Concepts

Abstract

We present herein the first synthesis of the water and air stable organometallic aqua complex [<sup>99m</sup>Tc(OH<sub>2</sub>)<sub>3</sub>(CO)<sub>3</sub>]<sup>+</sup> directly from [<sup>99m</sup>TcO<sub>4</sub>]<sup>-</sup> in saline under 1 atm of CO. Subsequent substitution of the labile water ligands by a bifunctional ligand attachable to biomolecules enables the introduction of carbonyl complexes in life sciences in general and in nuclear medicine in particular. [...]

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