Studies on Cytochrome P-450-Mediated Bioactivation of Diclofenac in Rats and in Human Hepatocytes: Identification of Glutathione Conjugated Metabolites

Diclofenac-associated hepatotoxicity: Analysis of 180 cases reported to the food and drug administration as adverse reactions

Alpha Banks, Hyman J. Zimmerman, Kamal G. Ishak et al. · Hepatology · 1995 · 294 citations · Full text

Pharmacy, Pharmacology, Toxicology +10

Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4′-hydroxylation in human liver

T. Leemann, C. Transon, Pierre Dayer · Life Sciences · 1993 · 267 citations

Medicine, Pharmacokinetics, Pharmacology +17

Diclofenac Covalent Protein Binding Is Dependent on Acyl Glucuronide Formation and Is Inversely Related to P450-Mediated Acute Cell Injury in Cultured Rat Hepatocytes

Urs A. Boelsterli · Toxicology and Applied Pharmacology · 1993 · 172 citations

Medicine, Biochemistry, Pharmacology +14

Diclofenac-Associated Hepatotoxicity

Simon M. Helfgott · JAMA · 1990 · 122 citations

Pharmacy, Pharmacology, Pharmacotherapy +14

Metabolic Activation and Immunochemical Localization of Liver Protein Adducts of the Nonsteroidal Anti-inflammatory Drug Diclofenac

Sally J. Hargus, Hamid R. Amouzedeh, Neil R. Pumford et al. · Chemical Research in Toxicology · 1994 · 106 citations

Pharmacy, Pharmacology, Toxicology +16