Role of AKT and ERK pathways in controlling sensitivity to ionizing radiation and adaptive response induced by low-dose radiation in human immune cells

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

Tomohiko Maehama, Jack E. Dixon · Journal of Biological Chemistry · 1998 · 3.1K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

PHLPP: A Phosphatase that Directly Dephosphorylates Akt, Promotes Apoptosis, and Suppresses Tumor Growth

Tianyan Gao, Frank B. Furnari, Alexandra C. Newton · Molecular Cell · 2005 · 911 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms

John Brognard, Emma Sierecki, Tianyan Gao et al. · Molecular Cell · 2007 · 578 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.

Mirjana Andjelković, Teresa Jakubowicz, Peter Cron et al. · Proceedings of the National Academy of Sciences · 1996 · 496 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Differential responses of stress genes to low dose-rate gamma irradiation.

Sally A. Amundson, Richard Anthony Lee, Christine A. Koch-Paiz et al. · PubMed · 2003 · 236 citations

Medicine, Cell Biology, Molecular Biology +16