A novel family of diarylpyrimidines (DAPYs) featuring a diatomic linker: Design, synthesis and anti-HIV activities

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

Françoise Barré‐Sinoussi, Jean‐Claude Chermann, FA Rey et al. · Science · 1983 · 6.9K citations

Primary Immunodeficiency, Htlv P24, Diagnostic Virology +15

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Rudi Pauwels, Jan Balzarini, Masanori Baba et al. · Journal of Virological Methods · 1988 · 1.6K citations

Medicinal Chemistry, Bioassay-guided Isolation, Tetrazolium-based Colorimetric Assay +12

Surflex:  Fully Automatic Flexible Molecular Docking Using a Molecular Similarity-Based Search Engine

Ajay N. Jain · Journal of Medicinal Chemistry · 2003 · 1.3K citations

Characterization of PicoGreen Reagent and Development of a Fluorescence-Based Solution Assay for Double-Stranded DNA Quantitation

Victoria L. Singer, Laurie J. Jones, Stephen Yue et al. · Analytical Biochemistry · 1997 · 768 citations

Biochemistry, Picogreen Reagent, Natural Sciences +13

Scoring noncovalent protein-ligand interactions: A continuous differentiable function tuned to compute binding affinities

Ajay N. Jain · Journal of Computer-Aided Molecular Design · 1996 · 602 citations

Protein Folding, Medicine, Molecular Biology +9