Concepedia

Presenilin is required for activity and nuclear access of Notch in Drosophila

Gary Struhl, Iva Greenwald

Nature · 1999 · 806 citations · 25 references

DOI

Concepts

References

25

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Bart De Strooper, Paul Säftig, Katleen Craessaerts et al. · Nature · 1998 · 1.8K citations

, , +15

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Eric H. Schroeter, Jeffrey A. Kisslinger, Raphael Kopan · Nature · 1998 · 1.6K citations

, , +13

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

Jie Shen, Roderick T. Bronson, Dongfeng Chen et al. · Cell · 1997 · 957 citations · Full text

, , +10

Nuclear Access and Action of Notch In Vivo

Gary Struhl, Atsuko Adachi · Cell · 1998 · 735 citations · Full text

, , +15

The Notch1 receptor is cleaved constitutively by a furin-like convertase

Frédérique Logeat, Christine Bessia, Christel Brou et al. · Proceedings of the National Academy of Sciences · 1998 · 733 citations

, , +17