Nuclear Organization

Nuclear organization is the hierarchical spatial arrangement of chromatin and associated nuclear macromolecules within the interphase nucleus that establishes functionally distinct domains coordinating transcription, replication, and genome regulation.

15.3K

Publications

1.1M

Citations

45.9K

Authors

4.8K

Institutions

Publications per year

2017–2026

1.5K

Parents

Cell Biology

Children

ChromatinChromatin ArchitectureChromosome TerritoriesEuchromatin OrganizationGenome CompartmentalizationHeterochromatin OrganizationLamina-associated DomainsNuclear ArchitectureNuclear BodiesNuclear Envelope

Publications

15.3K

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

Yael Gavrieli, Yoav Sherman, Shmuel A. Ben‐Sasson · The Journal of Cell Biology · 1992 · 9.5K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Global analysis of protein localization in budding yeast

Won‐Ki Huh, James V. Falvo, Luke C. Gerke et al. · Nature · 2003 · 4.4K citations

Life Sciences, Cell Biology, Molecular Biology +14

Synthesis of the Elements in Stars

E. M. Burbidge, G. R. Burbidge, William A. Fowler et al. · Reviews of Modern Physics · 1957 · 4K citations · Full text

Natural Sciences, Physics, Nuclear Organization +8

Controlled silver-staining of nucleolus organizer regions with a protective colloidal developer: a 1-step method

W. Mike Howell, D. Ann Black · Cellular and Molecular Life Sciences · 1980 · 2.9K citations

Medicine, Cell Biology, Molecular Biology +11

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

Kyle J. Roux, Dae In Kim, Manfred Raida et al. · The Journal of Cell Biology · 2012 · 2.6K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

1–5 of 15.3K

Authors

45.9K

WW
Werner W. Franke
German Cancer Research Center, Germany
61 publications · 5.5K citations
43
h-index
GB
Günter Blobel
Rockefeller University, United States
42 publications · 9.7K citations
42
h-index
LG
Larry Gerace
Scripps Research Institute, United States
46 publications · 11.4K citations
39
h-index
AI
Angus I. Lamond
University of Dundee, United Kingdom
42 publications · 5.6K citations
38
h-index
KL
Katherine L. Wilson
Johns Hopkins University, United States
36 publications · 4.7K citations
33
h-index

1–5 of 45.9K

Institutions

4.8K

1–8 of 4.8K

Venues

The Journal of Cell Biology
JCB · 937 publications · 141.5K citations
197
h-index
Proceedings of the National Academy of Sciences
PNAS · 482 publications · 58.9K citations
139
h-index
Journal of Cell Science
776 publications · 53.7K citations
121
h-index
Cell
163 publications · 57.9K citations
119
h-index
Journal of Biological Chemistry
JBC · 644 publications · 51.8K citations
117
h-index

1–5

See also Nuclear Organization
Structural Domains	Nuclear Lamina Chromosome Territories Nuclear Speckles Chromatin Loops Lamina-associated Domains Nucleolus-associated Domains A/b Chromatin Compartments Topologically Associating Domains
Functional Roles	Chromatin Transcriptional Regulation Transcriptional Repression Spatial Compartmentalization Replication Timing Profiles Dna Repair
Organizing Mechanisms	Loop Extrusion Liquid-liquid Phase Separation Condensin Complexes Polymer Physics Chromatin-lamina Interactions Nuclear Deformation Parameters
Measurement Techniques	Electron Microscopy Chromosome Conformation Capture Super-resolution Microscopy Cryo-electron Microscopy Live-cell Imaging Structured Illumination Microscopy Transmission Electron Microscopy Single-cell Hi-c In Situ Hybridization Photoactivated Localization Microscopy Direct Stochastic Optical Reconstruction Microscopy Circular Chromosome Conformation Capture Hi-c Scanning Electron Microscopy Scanning Transmission Electron Microscopy Micro-c
Dynamic Changes	Mitosis Lamin A/c Transcription Factories Radial Chromosome Arrangement Malignant Breast Tumors Gene Locus Relocation Cellular Reprogramming Transcriptional Silencing During Condensation