Concepedia

Liquid-liquid Phase Separation

Liquid–Liquid Phase Separation is a biophysical process in which a homogeneous solution of biomolecules spontaneously segregates into two distinct liquid phases, one enriched in macromolecules such as proteins or nucleic acids and the other depleted, driven by weak multivalent interactions that promote the formation of membrane-less condensates associated with cellular organization and regulation.

2.5K

Publications

170K

Citations

10K

Authors

2K

Institutions

Publications per year

2017–2026

1.4K

Variants

Llps

Parents

Publications

2.5K

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

Marina Feric, Nilesh Vaidya, Tyler S. Harmon et al. · Cell · 2016 · 2.1K citations · Full text

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Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

Adam G. Larson, Daniel Elnatan, Madeline M Keenen et al. · Nature · 2017 · 1.8K citations

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Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

Yuan Lin, David S.W. Protter, Michael K. Rosen et al. · Molecular Cell · 2015 · 1.7K citations · Full text

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Separation of Liquid Phases in Giant Vesicles of Ternary Mixtures of Phospholipids and Cholesterol

Sarah L. Veatch, Sarah L. Keller · Biophysical Journal · 2003 · 1.5K citations · Full text

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The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

Shana Elbaum‐Garfinkle, Younghoon Kim, Krzysztof Szczepaniak et al. · Proceedings of the National Academy of Sciences · 2015 · 1.4K citations · Full text

, , +15

1–5 of 2.5K

Authors

10K

  1. JM
    Jeetain Mittal

    Lehigh University, United States

    29 publications · 5.2K citations

    24

    h-index

  2. FS
    Frank Schreiber

    University of Tübingen, Germany

    19 publications · 1.1K citations

    17

    h-index

  3. GB
    George B. Benedek

    Massachusetts Institute of Technology, United States

    18 publications · 2.1K citations

    17

    h-index

  4. FZ
    Fajun Zhang

    University of Tübingen, Germany

    19 publications · 1.1K citations

    17

    h-index

  5. RK
    R. Koningsveld

    DSM (Netherlands), Netherlands

    18 publications · 1.3K citations

    16

    h-index

1–5 of 10K

Institutions

2K

  1. Centre National de la Recherche Scientifique

    Paris, France

    41 h-index

    353 publications

    20.9K citations

  2. Chinese Academy of Sciences

    Beijing, China

    36 h-index

    295 publications

    19.6K citations

  3. University of Chinese Academy of Sciences

    Beijing, China

    35 h-index

    232 publications

    18.9K citations

  4. ETH Zurich

    Zurich, Switzerland

    28 h-index

    181 publications

    17.2K citations

  5. University of Cambridge

    Cambridge, United Kingdom

    28 h-index

    171 publications

    12.2K citations

  6. Pennsylvania State University

    State College, United States

    27 h-index

    98 publications

    7.9K citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    26 h-index

    89 publications

    22.3K citations

  8. Tsinghua University

    Beijing, China

    26 h-index

    137 publications

    7.4K citations

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Venues

  1. Nature Communications

    91 publications · 11.3K citations

    58

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 65 publications · 9.9K citations

    49

    h-index

  3. The Journal of Physical Chemistry B

    66 publications · 3.5K citations

    36

    h-index

  4. Journal of the American Chemical Society

    JACS · 49 publications · 3.5K citations

    34

    h-index

  5. Physical Review Letters

    PRL · 40 publications · 4.2K citations

    33

    h-index

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