The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

Thomas A. Kunkel, John D. Roberts, Richard A. Zakour · Methods in enzymology on CD-ROM/Methods in enzymology · 1987 · 5.3K citations

Efficient Site-specific Mutagenesis, Genetics, Directed Evolution +5

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

Christine Koch, Deborah H. Anderson, Michael F. Moran et al. · Science · 1991 · 1.9K citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

Eve J. Lowenstein, Roger J. Daly, Andreas Batzer et al. · Cell · 1992 · 1.6K citations · Full text

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

Xiao‐Jian Sun, Paul Rothenberg, C. Ronald Kahn et al. · Nature · 1991 · 1.6K citations

Signal Transduction, Molecular Physiology, Biochemistry +9

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

Giuliana Pelicci, Luisa Lanfrancone, F Grignani et al. · Cell · 1992 · 1.3K citations

Signal Transduction, Signaling Pathway, Protein Expression +11