Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Xinsheng Nan, Huck‐Hui Ng, Colin A. Johnson et al. · Nature · 1998 · 3.4K citations

Histone Modifications, Chromatin, Transcriptional Regulation +13

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Peter Carmeliet, Yuval Dor, Jean-Marc Herbert et al. · Nature · 1998 · 2.5K citations

Tumor Biology, Hypoxia-mediated Apoptosis, Redox Regulator +15

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

Hua Zhong, Angelo M. De Marzo, Erik Laughner et al. · PubMed · 1999 · 2.2K citations

Pathology, Cancer Biology, Tumor Biology +19

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

Elizabeth E. Cameron, Kurtis E. Bachman, Sanna Myöhänen et al. · Nature Genetics · 1999 · 1.9K citations

Histone Modifications, Chromatin, Radiation Oncology +12

HIF-1alpha is required for solid tumor formation and embryonic vascularization

Heather E. Ryan · The EMBO Journal · 1998 · 1.6K citations · Full text

Tumor Biology, Oncology, Developmental Biology +9