Publication | Open Access
Participation of CYP2C8 and CYP3A4 in the N‐demethylation of imatinib in human hepatic microsomes
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References
2010
Year
CYP2C8 and CYPs 3A contribute to imatinib N-demethylation in human liver. The involvement of CYP2C8 may account in part for the wide inter-patient variation in imatinib pharmacokinetics observed in clinical practice.
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