Concepedia

Participation of CYP2C8 and CYP3A4 in the N‐demethylation of imatinib in human hepatic microsomes

Noelia Nebot, Séverine Crettol, Fabrizio D’Esposito, Bruce N. Tattam, David E. Hibbs, Michael T. Murray

British Journal of Pharmacology · 2010 · 87 citations · 36 references

DOIFull text

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Abstract

CYP2C8 and CYPs 3A contribute to imatinib N-demethylation in human liver. The involvement of CYP2C8 may account in part for the wide inter-patient variation in imatinib pharmacokinetics observed in clinical practice.

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