<scp>ABT</scp>‐263 enhances sorafenib‐induced apoptosis associated with <scp>A</scp>kt activity and the expression of <scp>B</scp>ax and p21⁽<scp>^CIP1/WAF1</scp>⁾ in human cancer cells

Abstract

The anti-tumour activity of ABT-263 plus sorafenib may involve the induction of intrinsic cell apoptosis via inhibition of Akt, and reduced Bax and p21 expression. Our findings offer a novel effective therapeutic strategy for tumour treatment.