Concepedia

Targeted In Vivo Delivery of siRNA and an Endosome-Releasing Agent to Hepatocytes

Magdolna G. Sebestyén, So C. Wong, Vladimir S. Trubetskoy, David L. Lewis, Christine I. Wooddell

Methods in molecular biology · 2014 · 51 citations · 20 references

DOI

Concepts

References

20

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

Jennifer A. Lockridge, Lucinda Shaw, Karin S. Blanchard et al. · Nature Biotechnology · 2005 · 1.2K citations

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Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

Christian Wolfrum, Shuanping Shi, K. N. Jayaprakash et al. · Nature Biotechnology · 2007 · 965 citations

, , +14

High Levels of Foreign Gene Expression in Hepatocytes after Tail Vein Injections of Naked Plasmid DNA

G Zhang, Vladimir G. Budker, Jon A. Wolff · Human Gene Therapy · 1999 · 950 citations

, , +14

Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing

Aimee L. Jackson, Julja Burchard, Devin Leake et al. · RNA · 2006 · 788 citations · Full text

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Dynamic PolyConjugates for targeted <i>in vivo</i> delivery of siRNA to hepatocytes

David B. Rozema, David L. Lewis, Darren H. Wakefield et al. · Proceedings of the National Academy of Sciences · 2007 · 679 citations · Full text

, , +17