Darren H. Wakefield

Dynamic PolyConjugates for targeted <i>in vivo</i> delivery of siRNA to hepatocytes

David B. Rozema, David L. Lewis, Darren H. Wakefield et al. · Proceedings of the National Academy of Sciences · 2007 · 679 citations · Full text

Engineering, Molecular Biology, Gene Delivery +17

Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection

Christine I. Wooddell, David B. Rozema, Matthias John et al. · Molecular Therapy · 2013 · 289 citations · Full text

Co-Injection of a Targeted, Reversibly Masked Endosomolytic Polymer Dramatically Improves the Efficacy of Cholesterol-Conjugated Small Interfering RNAs <i>In Vivo</i>

So C. Wong, Jason J. Klein, Holly Hamilton et al. · Nucleic Acid Therapeutics · 2012 · 100 citations · Full text

Membrane Activity and Transfection Ability of Amphipathic Polycations as a Function of Alkyl Group Size

Darren H. Wakefield, Jason J. Klein, Jon A. Wolff et al. · Bioconjugate Chemistry · 2005 · 47 citations

Membrane-active Peptides, Engineering, Membrane Lysis +18

Protease-triggered siRNA delivery vehicles

David B. Rozema, Andrei V. Blokhin, Darren H. Wakefield et al. · Journal of Controlled Release · 2015 · 40 citations · Full text