Matthias John

RNAi-mediated gene silencing in non-human primates

Tracy Zimmermann, Amy C. H. Lee, Akin Akinc et al. · Nature · 2006 · 1.3K citations

Life Sciences, Genetics, Molecular Biology +8

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Akin Akinc, Andreas Zumbuehl, Michael S. Goldberg et al. · Nature Biotechnology · 2008 · 1.2K citations

Pharmacy, Molecular Biology, Molecular Pharmaceutics +16

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

Maria Frank-Kamenetsky, Aldo Grefhorst, Norma N. Anderson et al. · Proceedings of the National Academy of Sciences · 2008 · 639 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells

Christina Lorenz, Philipp Hadwiger, Matthias John et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 334 citations

Life Sciences, Genetics, Molecular Biology +17

Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection

Christine I. Wooddell, David B. Rozema, Matthias John et al. · Molecular Therapy · 2013 · 292 citations · Full text

Pharmacy, Molecular Medicine, Pharmaceutics +16