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The omega‐3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC‐26 colorectal cancer cell liver metastasis via inhibition of PGE<sub>2</sub>‐dependent cell motility

DOIFull Paper Access

53

Citations

31

References

2012

Year

Gillian Hawcroft, Milène Volpato, Gemma Marston, Nicola Ingram, SL Perry, AD Race, Alessandra Munarini, Andrea Belluzzi, PL Coletta, MA Hull
British Journal of Pharmacology

Abstract

EPA-FFA inhibits MC-26 CRC cell liver metastasis. EPA incorporation is associated with a 'PGE(2) to PGE(3) switch' in liver tumours. Inhibition of PGE(2)-EP(4) receptor-dependent CRC cell motility probably contributes to the antineoplastic activity of EPA.

References

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