Concepedia

Polymorphism of ITPA 94C>A and risk of adverse effects among patients with acute lymphoblastic leukaemia treated with 6-mercaptopurine

Wan Rosalina Wan Rosli, Lay Kek Teh, Norsarwany Mohamad, Ariffin Nasir, Rozita Yusoff, Aziz Baba, Mohd Zaki Salleh

Journal of Clinical Pharmacy and Therapeutics · 2011 · 47 citations · 10 references

Abstract

Our results suggest that ITPA 94C>A testing, but not TPMT testing, may help in minimizing the adverse effects of 6-MP in Malaysian patients. However, whether this is true in clinical practice requires a larger study and formal randomized controlled evaluation.

References

10

Basic local alignment search tool

Stephen F. Altschul, Warren Gish, Webb Miller et al. · Journal of Molecular Biology · 1990 · 92.8K citations

Bioinformatics, Engineering, Information Retrieval +10

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase)

Anthony M. Marinaki, Azhar Ansari, John A. Duley et al. · Pharmacogenetics · 2004 · 322 citations

Inflammation, Drug Hypersensitivity, Inosine Triphosphate Pyrophosphatase +14

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency

Satoshi Sumi, Anthony M. Marinaki, Monica Arenas et al. · Human Genetics · 2002 · 267 citations

Genetic Disorder, Genetics, Biochemical Genetics +4

Mutagenically separated PCR (MS-PCR): a highly specific one step procedure for easy mutation detection

Stephan Rust, Harald Funke, Gerd Assmann · Nucleic Acids Research · 1993 · 245 citations · Full text

Step Procedure, Genetic Testing, Genetics +25

Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity.

Diane M. Otterness, C. L. Szumlanski, Thomas C. Wood et al. · Journal of Clinical Investigation · 1998 · 118 citations · Full text

Genetics, Molecular Biology, Gene Characterization +17