Concepedia

Tpmt Variant Testing

TPMT Variant Testing is a pharmacogenomic assay that identifies genetic polymorphisms in the thiopurine S-methyltransferase gene to predict individual metabolic capacity for thiopurine drugs and guide personalized chemotherapy dosing.

42

Publications

2.2K

Citations

461

Authors

169

Institutions

Publications per year

2017–2026

4

Parents

Publications

42

Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease

Marieke J. H. Coenen, Dirk J. de Jong, Corine J. van Marrewijk et al. · Gastroenterology · 2015 · 197 citations · Full text

, , +14

Association of Genetic Variants in <i>NUDT15</i> With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease

G Walker, Graham Heap, Michiel Voskuil et al. · JAMA · 2019 · 171 citations · Full text

, , +17

Genotypic and phenotypic analysis of the polymorphic thiopurine S‐methyltransferase gene (<i>TPMT</i>) in a European population

Catherine Spire‐Vayron de la Moureyre, Hervé Debuysère, B. Mastain et al. · British Journal of Pharmacology · 1998 · 171 citations · Full text

, , +15

Susceptibility to 6‐<scp>MP</scp> toxicity conferred by a <i><scp>NUDT</scp>15</i> variant in Japanese children with acute lymphoblastic leukaemia

Yoïchi Tanaka, Motohiro Kato, Daisuke Hasegawa et al. · British Journal of Haematology · 2015 · 128 citations · Full text

, , +15

Detection of known and new mutations in the thiopurineS-methyltransferase gene by single-strand conformation polymorphism analysis

Catherine Spire‐Vayron de la Moureyre, Hervé Debuysère, Nadda Sabbagh et al. · Human Mutation · 1998 · 110 citations

, , +17

1–5 of 42

Authors

461

  1. RB
    Richard B. Gearry

    University of Otago, New Zealand

    2 publications · 84 citations

    2

    h-index

  2. ML
    Murray L. Barclay

    Christchurch Hospital, New Zealand

    2 publications · 84 citations

    2

    h-index

  3. JL
    Jean‐Marc Lo‐Guidice

    Université de Lille, France

    2 publications · 281 citations

    2

    h-index

  4. CH
    Chew‐Kiat Heng

    National University of Singapore, Singapore

    2 publications · 95 citations

    2

    h-index

  5. HD
    Hervé Debuysère

    Hôpital Albert Calmette, France

    2 publications · 281 citations

    2

    h-index

1–5 of 461

Institutions

169

  1. National University of Singapore

    Singapore, Singapore

    3 h-index

    8 publications

    304 citations

  2. Calmette Hospital

    Phnom Penh, Cambodia

    2 h-index

    2 publications

    281 citations

  3. Hôpital Albert Calmette

    Lille, France

    2 h-index

    18 publications

    2.6K citations

  4. University of Otago

    Dunedin, New Zealand

    2 h-index

    7 publications

    284 citations

  5. Tan Tock Seng Hospital

    Singapore, Singapore

    2 h-index

    5 publications

    95 citations

  6. Linköping University

    Linköping, Sweden

    2 h-index

    5 publications

    365 citations

  7. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology

    Stuttgart, Germany

    2 h-index

    9 publications

    865 citations

  8. Centre Hospitalier Universitaire de Lille

    Lille, France

    2 h-index

    26 publications

    4K citations

1–8 of 169

Venues

  1. PubMed

    Repository · 2 publications · 25 citations

    2

    h-index

  2. British Journal of Clinical Pharmacology

    BJCP · 2 publications · 112 citations

    2

    h-index

  3. Clinical Chemistry

    2 publications · 195 citations

    2

    h-index

  4. Human Mutation

    2 publications · 141 citations

    2

    h-index

  5. Pharmacogenetics and Genomics

    2 publications · 87 citations

    2

    h-index

1–5