Concepedia

Chemical Stability of Insulin. 1. Hydrolytic Degradation During Storage of Pharmaceutical Preparations

Jens Brange, Liselotte Langkjsgmaelig r, Svend Havelund, Aage Vølund

Pharmaceutical Research · 1992 · 146 citations · 25 references

DOI

Concepts

References

25

Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.

Terrence L. Geiger, Steven Clarke · Journal of Biological Chemistry · 1987 · 1.3K citations · Full text

, , +16

The structure of 2Zn pig insulin crystals at 1.5 Å resolution

Edward N. Baker, T.L. Blundell, J.F. Cutfield · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1988 · 673 citations

, , +17

Succinimide Formation from Aspartyl and Asparaginyl Peptides as a Model for the Spontaneous Degradation of Proteins

Robert C. Stephenson, Steven Clarke · Journal of Biological Chemistry · 1989 · 518 citations · Full text

, , +14

[14] Cleavage at AsnGly bonds with hydroxylamine

Paul Börnstein, Gary Balian · Methods in enzymology on CD-ROM/Methods in enzymology · 1977 · 417 citations

, , +9

Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins

Steven Clarke · International journal of peptide & protein research · 1987 · 335 citations

, , +16