Concepedia

Evaluation of a Targeted Prodrug Strategy to Enhance Oral Absorption of Poorly Water-Soluble Compounds

O. Helen Chan, Heidi L. Schmid, Linda Stilgenbauer, William Howson, David C. Horwell, Barbra H. Stewart

Pharmaceutical Research · 1998 · 24 citations · 11 references

DOI

Concepts

References

11

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

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Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin

Harold Boxenbaum · Journal of Pharmacokinetics and Biopharmaceutics · 1980 · 343 citations

, , +17

Comparison of Intestinal Permeabilities Determined in Multiple in Vitro and inSitu Models: Relationship to Absorption in Humans

Barbra H. Stewart, O. Helen Chan, Rosalind H. Lu et al. · Pharmaceutical Research · 1995 · 186 citations

, , +12

Improved oral drug delivery: solubility limitations overcome by the use of prodrugs

David Fleisher, Ramon Bong, Barbra H. Stewart · Advanced Drug Delivery Reviews · 1996 · 129 citations

, , +14

H+ gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine.

Ai Tsuji, Tetsuya Terasaki, Ikumi Tamai et al. · Journal of Pharmacology and Experimental Therapeutics · 1987 · 110 citations

, , +17