David C. Horwell

Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.

Joel W. Hughes, P. Boden, B. Costall et al. · Proceedings of the National Academy of Sciences · 1990 · 504 citations

Medicine, Medicinal Chemistry, Pharmacology +13

Rationally designed "dipeptoid" analogs of CCK. .alpha.-Methyltryptophan derivatives as highly selective and orally active gastrin and CCK-B antagonists with potent anxiolytic properties

David C. Horwell, Martyn C. Pritchard, Edward Roberts et al. · Journal of Medicinal Chemistry · 1991 · 174 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

PD134308, a selective antagonist of cholecystokinin type B receptor, enhances the analgesic effect of morphine and synergistically interacts with intrathecal galanin to depress spinal nociceptive reflexes.

Z. Wiesenfeld‐Hallin, Joel W. Hughes, David C. Horwell et al. · Proceedings of the National Academy of Sciences · 1990 · 168 citations

Medicine, Neurobiology, Pharmacology +17

CI‐977, a novel and selective agonist for the κ‐opioid receptor

John C. Hunter, G.E. Leighton, Ken Meecham et al. · British Journal of Pharmacology · 1990 · 154 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Identification of Novel Ligands for the Gabapentin Binding Site on the α₂δ Subunit of a Calcium Channel and Their Evaluation as Anticonvulsant Agents

Justin S. Bryans, Natasha Davies, N S Gee et al. · Journal of Medicinal Chemistry · 1998 · 92 citations

Medicine, Medicinal Chemistry, Pharmacology +15