Concepedia

Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD<sub>2</sub>pathway

Pengyun Li, Xingmin Wang, Ming Zhao, Rui Song, Ke‐seng Zhao

Expert Opinion on Therapeutic Targets · 2015 · 60 citations · 29 references

DOI

Abstract

PD effectively preserved hepatocytes from mitochondrial injury via SIRT1-SOD2 pathway and may be a new approach to treatment of irreversible shock.

References

29

Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

Julie St‐Pierre, Stavit Drori, Marc Uldry et al. · Cell · 2006 · 2.2K citations · Full text

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Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Geert J.P.L. Kops, Tobias B. Dansen, Paulien E. Polderman et al. · Nature · 2002 · 1.5K citations

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Ana P. Gomes, Nathan L. Price, Alvin J. Y. Ling et al. · Cell · 2013 · 1.4K citations · Full text

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Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart

Ralph R. Alcendor, Shumin Gao, Peiyong Zhai et al. · Circulation Research · 2007 · 1.1K citations

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[29] Mitochondrial membrane potential monitored by JC-1 dye

Martin Reers, Stephen T. Smiley, C Mottola-Hartshorn et al. · Methods in enzymology on CD-ROM/Methods in enzymology · 1995 · 680 citations

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