Ubiquitous Induction of p53 in Tumor Cells by Antisense Inhibition of MDM2 Expression

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations

Life Sciences, Cancer Biology, Molecular Biology +10

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature · 1997 · 3.3K citations

Life Sciences, Cancer Biology, Molecular Biology +10

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

Medicine, Molecular Biology, Oncology +10

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

Scott W. Lowe, H. Earl Ruley, Tyler Jacks et al. · Cell · 1993 · 2.9K citations

Life Sciences, Cancer Biology, Oncology +14

p53 is required for radiation-induced apoptosis in mouse thymocytes

Scott W. Lowe, Earlene M. Schmitt, Sallie W. Smith et al. · Nature · 1993 · 2.9K citations

Medicine, Cell Biology, Oncology +14