Concepedia

Comprehensive Analysis of the Therapeutic IgG4 Antibody Pembrolizumab: Hinge Modification Blocks Half Molecule Exchange In Vitro and In Vivo

Xiaoyu Yang, Fengqiang Wang, Ying Zhang, Larry Wang, S. V. Antonenko, Shuli Zhang, Yi Wei Zhang, Mohammad A. Tabrizi‐Fard, Grigori Ermakov, Derek Wiswell,

Journal of Pharmaceutical Sciences · 2015 · 39 citations · 22 references

DOI

Concepts

References

22

Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

Marijn van der Neut Kolfschoten, Janine Schuurman, Mario Losen et al. · Science · 2007 · 975 citations

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Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange

Aran F. Labrijn, Joyce Meesters, Bart E.C.G. de Goeij et al. · Proceedings of the National Academy of Sciences · 2013 · 330 citations · Full text

, , +17

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

Aran F. Labrijn, Antonio Ortiz Buijsse, Ewald T.J. van den Bremer et al. · Nature Biotechnology · 2009 · 290 citations

, , +10

Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms

Jette Wypych, Ming Li, Amy Guo et al. · Journal of Biological Chemistry · 2008 · 282 citations · Full text

, , +15

Contrasting IgG Structures Reveal Extreme Asymmetry and Flexibility

Erica Ollmann Saphire, Robyn L. Stanfield, Max Crispin et al. · Journal of Molecular Biology · 2002 · 246 citations

, , +10