Concepedia

Specific phosphopeptide binding regulates a conformational change in the PI 3‐kinase SH2 domain associated with enzyme activation.

Steven E. Shoelson, Mohanram Sivaraja, Kevin P. Williams, Patrick J Hu, Joseph Schlessinger, Michael A. Weiss

The EMBO Journal · 1993 · 175 citations · 38 references

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References

38

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

Donald B. Smith, Kevin S. Johnson · Gene · 1988 · 6K citations

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SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

Christine Koch, Deborah H. Anderson, Michael F. Moran et al. · Science · 1991 · 1.9K citations

, , +17

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

Eve J. Lowenstein, Roger J. Daly, Andreas Batzer et al. · Cell · 1992 · 1.7K citations · Full text

, , +17

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

Xiao‐Jian Sun, Paul Rothenberg, C. Ronald Kahn et al. · Nature · 1991 · 1.6K citations

, , +14

Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation.

Jonathan Backer, Martin G. Myers, Steven E. Shoelson et al. · The EMBO Journal · 1992 · 1K citations · Full text

, , +12