Aggregates Formed During Storage of β-Galactosidase in Solution and in the Freeze-Dried State

The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone

Michael J. Pikal, Karen M. Dellerman, R.M. Riggin · Pharmaceutical Research · 1991 · 273 citations

Pharmacy, Food Science, Pharmaceutics +14

Moisture‐induced aggregation of lyophilized proteins in the solid state

Wei Liu, Róbert Langer, Alexander M. Klibanov · Biotechnology and Bioengineering · 1991 · 262 citations

Life Sciences, Biochemistry, Drug Delivery +16

Lyophilized Formulations of Recombinant Tumor Necrosis Factor

Maninder Hora, Rajsharan K. Rana, Flint W. Smith · Pharmaceutical Research · 1992 · 66 citations

Pharmacy, Pharmaceutical Biotechnology, Pharmaceutics +12

Use of lyoprotectants in the freeze-drying of a model protein, ribonuclease A.

Michael Townsend, Patrick P. DeLuca · PubMed · 1989 · 63 citations

Life Sciences, Biochemistry, Molecular Biology +17

Stability of Ribonuclease A in Solution and the Freeze-Dried State

Michael Townsend, Patrick P. DeLuca · Journal of Pharmaceutical Sciences · 1990 · 48 citations

Life Sciences, Biochemistry, Molecular Biology +14