Exploring the functional robustness of an enzyme by in vitro evolution.

Rapid evolution of a protein in vitro by DNA shuffling

Willem P.C. Stemmer · Nature · 1994 · 1.9K citations

Dna Sequencing, Natural Sciences, Genetics +11

DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution.

Willem PC Stemmer · Proceedings of the National Academy of Sciences · 1994 · 1.3K citations

Reverse Genetics, Genetics, Molecular Biology +22

Randomization of genes by PCR mutagenesis.

R C Cadwell, Gerald F. Joyce · Genome Research · 1992 · 1.1K citations · Full text

Random Point Mutations, Engineering, Reverse Genetics +17

DNA recombination during PCR

Andreas Meyerhans, Jean‐Pierre Vartanian, Simon Wain–Hobson · Nucleic Acids Research · 1990 · 579 citations · Full text

Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions

James U. Bowie, John F. Reidhaar-Olson, Wendell A. Lim et al. · Science · 1990 · 486 citations

Genetics, Protein Folds, Molecular Biology +18