Arisaph Pharmaceuticals (United States)

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

Marian C. Okondo, Darren C. Johnson, Ramya Sridharan et al. · Nature Chemical Biology · 2016 · 300 citations · Full text

Inflammation, Signal Transduction, Apoptosis +9

Identification of Selective and Potent Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase

Sarah E. Poplawski, Jack H. Lai, Youhua Li et al. · Journal of Medicinal Chemistry · 2013 · 121 citations · Full text

Chemoprevention Strategy, Prolyl Oligopeptidase, Chemical Biology +16

A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity

Daniel A. Bachovchin, Luke W. Koblan, Wengen Wu et al. · Nature Chemical Biology · 2014 · 74 citations · Full text

Human FGF-21 Is a Substrate of Fibroblast Activation Protein

Andrew L. Coppage, Kathryn R. Heard, Matthew T. DiMare et al. · PLoS ONE · 2016 · 68 citations · Full text

Fap Cleavage Site, Human Fgf-21, Metabolic Remodeling +18

A pan inhibitor of DASH family enzymes induces immunogenic modulation and sensitizes murine and human carcinoma cells to antigen-specific cytotoxic T lymphocyte killing: implications for combination therapy with cancer vaccines

Renee N. Donahue, Brynn B. Duncan, Terry J. Fry et al. · Vaccine · 2014 · 14 citations

Cancer Immunosurveillance, Dash Family Enzymes, Pan Inhibitor +11