Concepedia

Zap-70 Activation

ZAP-70 Activation is a molecular signaling event, defined as the phosphorylation and subsequent activation of the zeta-chain-associated protein kinase 70 (ZAP-70) following T cell receptor engagement, which serves as a critical early step in the transduction of signals leading to T cell activation and downstream immune responses.

562

Publications

50.2K

Citations

3K

Authors

812

Institutions

Publications per year

2017–2026

46

Parents

Publications

562

A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia

George A. Calin, Manuela Ferracin, Amelia Cimmino et al. · New England Journal of Medicine · 2005 · 2.4K citations

, , +16

ZAP-70 Expression as a Surrogate for Immunoglobulin-Variable-Region Mutations in Chronic Lymphocytic Leukemia

Marta Crespo, Francesc Bosch, Neus Villamor et al. · New England Journal of Medicine · 2003 · 1.3K citations · Full text

, , +16

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

Andrew C. Chan, Makio Iwashima, Christoph W. Turck et al. · Cell · 1992 · 1K citations

, , +6

ZAP-70 Compared with Immunoglobulin Heavy-Chain Gene Mutation Status as a Predictor of Disease Progression in Chronic Lymphocytic Leukemia

Laura Z. Rassenti, Lang Huynh, Tracy L. Toy et al. · New England Journal of Medicine · 2004 · 906 citations

, , +15

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

Noriko Sakaguchi, Takeshi Takahashi, Hiroshi Hata et al. · Nature · 2003 · 875 citations

, , +14

1–5 of 562

Authors

3K

  1. AW
    Arthur Weiss

    Howard Hughes Medical Institute, United States

    43 publications · 8.7K citations

    37

    h-index

  2. AC
    Andrew C. Chan

    Howard Hughes Medical Institute, United States

    19 publications · 6.2K citations

    19

    h-index

  3. LE
    Lawrence E. Samelson

    National Institutes of Health, United States

    18 publications · 2.2K citations

    16

    h-index

  4. OA
    Oreste Acuto

    Institut Pasteur, France

    14 publications · 1.1K citations

    14

    h-index

  5. RL
    Ronald L. Wange

    National Institutes of Health, United States

    14 publications · 2.1K citations

    13

    h-index

1–5 of 3K

Institutions

812

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    45 h-index

    213 publications

    43.2K citations

  2. University of California, San Francisco

    San Francisco, United States

    36 h-index

    136 publications

    22.9K citations

  3. National Institutes of Health

    Bethesda, United States

    27 h-index

    130 publications

    15.6K citations

  4. Inserm

    Paris, France

    22 h-index

    123 publications

    6K citations

  5. Harvard University

    Cambridge, United States

    21 h-index

    102 publications

    8.6K citations

  6. Institut Pasteur

    Paris, France

    20 h-index

    83 publications

    6.9K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    17 h-index

    76 publications

    3.9K citations

  8. Washington University in St. Louis

    St Louis, United States

    15 h-index

    52 publications

    9.7K citations

1–8 of 812

Venues

  1. Journal of Biological Chemistry

    JBC · 58 publications · 5.2K citations

    42

    h-index

  2. The Journal of Immunology

    JI · 58 publications · 3.5K citations

    39

    h-index

  3. The Journal of Experimental Medicine

    36 publications · 4.1K citations

    33

    h-index

  4. Molecular and Cellular Biology

    MCB · 19 publications · 2.1K citations

    19

    h-index

  5. Blood

    21 publications · 3.1K citations

    19

    h-index

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