Noriko Sakaguchi

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

Takeshi Takahashi, Tomoyuki Tagami, Sayuri Yamazaki et al. · The Journal of Experimental Medicine · 2000 · 2.2K citations · Full text

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

Takamune Takahashi, Yuhshi Kuniyasu, Masaaki Toda et al. · International Immunology · 1998 · 1.5K citations · Full text

Normal Naive Mice, T-regulatory Cell, Cellular Immunology +19

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

Misako Itoh, Takeshi Takahashi, Noriko Sakaguchi et al. · The Journal of Immunology · 1999 · 1.2K citations · Full text

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

Keiji Hirota, Hiroyuki Yoshitomi, Motomu Hashimoto et al. · The Journal of Experimental Medicine · 2007 · 908 citations · Full text

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

Noriko Sakaguchi, Takeshi Takahashi, Hiroshi Hata et al. · Nature · 2003 · 858 citations

Rheumatology, Immunogenetics, Zap-70 Gene Causes +7