Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

Takeshi Takahashi, Tomoyuki Tagami, Sayuri Yamazaki, +5

The Journal of Experimental Medicine

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

Takamune Takahashi, Yuhshi Kuniyasu, Masaaki Toda, +5

International Immunology

Normal Naive MiceT-regulatory CellCellular ImmunologyImmunologyImmunologic Mechanism +17

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

Misako Itoh, Takeshi Takahashi, Noriko Sakaguchi, +4

The Journal of Immunology

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

Keiji Hirota, Hiroyuki Yoshitomi, Motomu Hashimoto, +9

The Journal of Experimental Medicine

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

Noriko Sakaguchi, Takeshi Takahashi, Hiroshi Hata, +8

Nature

RheumatologyImmunogeneticsZap-70 Gene CausesAutoimmune DiseaseT-regulatory Cell +5

Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine

Yuichi Maeda, Takashi Kurakawa, Eiji Umemoto, +15

Arthritis & Rheumatology

T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis

Keiji Hirota, Motomu Hashimoto, Hiroyuki Yoshitomi, +6

The Journal of Experimental Medicine

A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

Hiroyuki Yoshitomi, Noriko Sakaguchi, Katsuya Kobayashi, +11

The Journal of Experimental Medicine

Skg ArthritisImmunologyImmune RegulationPathologyInnate Immunity +15

Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell–mediated spontaneous autoimmune arthritis in mice

Hiroshi Hata, Noriko Sakaguchi, Hiroyuki Yoshitomi, +8

Journal of Clinical Investigation

Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell–mediated spontaneous autoimmune arthritis in mice

Hiroshi Hata, Noriko Sakaguchi, Hiroyuki Yoshitomi, +8

Journal of Clinical Investigation