Concepedia

Vector Safety Assessment

Vector Safety Assessment is a systematic evaluation procedure within ex vivo gene therapy research that identifies and characterizes potential biosafety risks associated with viral or non-viral vectors, distinguishing itself by its focus on vector-specific toxicities, insertional mutagenesis, immunogenicity, and replication-competent virus formation prior to clinical application.

78

Publications

6.3K

Citations

672

Authors

205

Institutions

Publications per year

2017–2026

29

Parents

Publications

78

Long-Term Safety and Efficacy of Factor IX Gene Therapy in Hemophilia B

Amit Nathwani, Ulreke M. Reiss, Edward G. D. Tuddenham et al. · New England Journal of Medicine · 2014 · 1.3K citations · Full text

, , +17

Treatment of Late Infantile Neuronal Ceroid Lipofuscinosis by CNS Administration of a Serotype 2 Adeno-Associated Virus Expressing CLN2 cDNA

Stefan Worgall, Dolan Sondhi, Neil R. Hackett et al. · Human Gene Therapy · 2008 · 404 citations

, , +16

Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy

Randy J. Chandler, Matthew C. LaFave, Gaurav K. Varshney et al. · Journal of Clinical Investigation · 2015 · 393 citations

, , +16

Assessing the potential for AAV vector genotoxicity in a murine model

Hojun Li, Nirav Malani, Shari R Hamilton et al. · Blood · 2010 · 228 citations · Full text

, , +15

Efficacy and safety of adeno‐associated viral vectors based on serotype 8 and 9 vs. lentiviral vectors for hemophilia B gene therapy

Thierry VandenDriessche, Lieven Thorrez, Abel Acosta‐Sanchez et al. · Journal of Thrombosis and Haemostasis · 2006 · 199 citations · Full text

, , +14

1–5 of 78

Authors

672

  1. RW
    Roland W. Herzog

    University of Florida, United States

    5 publications · 402 citations

    5

    h-index

  2. TJ
    Thomas J. Conlon

    University of Florida, United States

    4 publications · 311 citations

    4

    h-index

  3. BJ
    Barry J. Byrne

    University of Florida, United States

    4 publications · 402 citations

    4

    h-index

  4. KA
    Katherine A. High

    Children's Hospital of Philadelphia, United States

    4 publications · 1.7K citations

    4

    h-index

  5. JM
    James M. Wilson

    University of Pennsylvania, United States

    4 publications · 475 citations

    4

    h-index

1–5 of 672

Institutions

205

  1. University of Florida

    Gainesville, United States

    10 h-index

    51 publications

    4.4K citations

  2. University of Pennsylvania

    Philadelphia, United States

    9 h-index

    55 publications

    5.3K citations

  3. Cornell University

    Ithaca, United States

    6 h-index

    29 publications

    7.5K citations

  4. University College London

    London, United Kingdom

    6 h-index

    28 publications

    14.5K citations

  5. Florida College

    Temple Terrace, United States

    5 h-index

    19 publications

    1.4K citations

  6. Children's Hospital of Philadelphia

    Philadelphia, United States

    5 h-index

    25 publications

    7.2K citations

  7. The Ohio State University

    Columbus, United States

    4 h-index

    14 publications

    950 citations

  8. Nationwide Children's Hospital

    Columbus, United States

    4 h-index

    26 publications

    2.1K citations

1–8 of 205

Venues

  1. Human Gene Therapy

    11 publications · 1.1K citations

    11

    h-index

  2. Molecular Therapy

    11 publications · 803 citations

    11

    h-index

  3. 9

    h-index

  4. Human Gene Therapy Clinical Development

    5 publications · 333 citations

    5

    h-index

  5. PubMed

    Repository · 5 publications · 131 citations

    5

    h-index

1–5