Human Gene Therapy Clinical Development

AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease

Jonathan B. Rosenberg, Michael G. Kaplitt, Bishnu P. De et al. · 2018 · 162 citations · Full text

Medicine, Neurology, Neuroscience +14

Design of a Phase I Clinical Trial to Evaluate M032, a Genetically Engineered HSV-1 Expressing IL-12, in Patients with Recurrent/Progressive Glioblastoma Multiforme, Anaplastic Astrocytoma, or Gliosarcoma

Daxa Patel, Paul M. Foreman, Burt Nabors et al. · 2016 · 158 citations · Full text

Life Sciences, Immunology, Oncology +17

Long-Term Follow-Up of a Phase I/II Study of ProSavin, a Lentiviral Vector Gene Therapy for Parkinson's Disease

Stéphane Palfi, Jean Marc Gurruchaga, H. Lepetit et al. · 2018 · 142 citations · Full text

Medicine, Neurology, Neuroscience +17

Persistent Expression of Dopamine-Synthesizing Enzymes 15 Years After Gene Transfer in a Primate Model of Parkinson's Disease

Yoshihide Sehara, Ken’ichi Fujimoto, Kunihiko Ikeguchi et al. · 2017 · 140 citations

Medicine, Neurobiology, Neuroscience +17

Design of a Phase I Clinical Trial to Evaluate Intratumoral Delivery of ErbB-Targeted Chimeric Antigen Receptor T-Cells in Locally Advanced or Recurrent Head and Neck Cancer

May CI van Schalkwyk, Sophie Papa, Jean‐Pierre Jeannon et al. · 2013 · 123 citations

Medicine, Immunology, Oncology +17