Concepedia

Vector Genome Integration

Vector Genome Integration is a molecular biology process in which a gene delivery vector's genetic material is stably incorporated into the host cell's genome, distinguishing it from transient delivery mechanisms by enabling persistent transgene expression and inheritance during cell division.

42

Publications

5.4K

Citations

279

Authors

102

Institutions

Publications per year

2017–2026

8

Parents

Publications

42

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.

Luigi Naldini, Ulrike Blömer, Fred H. Gage et al. · Proceedings of the National Academy of Sciences · 1996 · 1.5K citations · Full text

, , +17

Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector

Douglas J. MacNeil, Keith M. Gewain, Carolyn L. Ruby et al. · Gene · 1992 · 761 citations

, , +9

High levels of AAV vector integration into CRISPR-induced DNA breaks

Killian S. Hanlon, Benjamin P. Kleinstiver, Sara P. Garcia et al. · Nature Communications · 2019 · 432 citations · Full text

, , +17

Advances in Non-Viral DNA Vectors for Gene Therapy

Cinnamon L Hardee, Lirio Milenka Arevalo-Soliz, Benjamin D. Hornstein et al. · Genes · 2017 · 351 citations · Full text

, , +13

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection

Alessandra Biffi, Cynthia C. Bartolomae, Daniela Cesana et al. · Blood · 2011 · 241 citations · Full text

, , +11

1–5 of 42

Authors

279

  1. EM
    Eugenio Montini

    The San Raffaele Telethon Institute for Gene Therapy, Italy

    6 publications · 876 citations

    6

    h-index

  2. CV
    Christof von Kalle

    National Center for Tumor Diseases, Germany

    5 publications · 604 citations

    5

    h-index

  3. MS
    Manfred Schmidt

    National Center for Tumor Diseases, Germany

    5 publications · 604 citations

    5

    h-index

  4. MG
    Markus Grompe

    Oregon Health & Science University, United States

    4 publications · 449 citations

    4

    h-index

  5. HN
    Hiroyuki Nakai

    Niigata University, Japan

    4 publications · 325 citations

    4

    h-index

1–5 of 279

Institutions

102

  1. National Center for Tumor Diseases

    Heidelberg, Germany

    5 h-index

    35 publications

    4.4K citations

  2. Heidelberg University

    Heidelberg, Germany

    4 h-index

    32 publications

    3.7K citations

  3. Oregon Health & Science University

    Portland, United States

    4 h-index

    8 publications

    933 citations

  4. University College London

    London, United Kingdom

    4 h-index

    16 publications

    1.7K citations

  5. Pediatrics and Genetics

    Alpharetta, United States

    3 h-index

    11 publications

    730 citations

  6. The San Raffaele Telethon Institute for Gene Therapy

    Milan, Italy

    3 h-index

    21 publications

    4.4K citations

  7. Stanford University

    Stanford, United States

    3 h-index

    15 publications

    1.3K citations

  8. University of Washington

    Seattle, United States

    3 h-index

    6 publications

    1K citations

1–8 of 102

Venues

  1. Molecular Therapy

    8 publications · 419 citations

    8

    h-index

  2. Journal of Virology

    JVI · 6 publications · 615 citations

    6

    h-index

  3. Gene

    3 publications · 854 citations

    3

    h-index

  4. Human Gene Therapy

    2 publications · 164 citations

    2

    h-index

  5. Blood

    2 publications · 266 citations

    2

    h-index

1–5