Concepedia

Vector Dose Optimization

Vector Dose Optimization is a methodological framework in systemic gene delivery that systematically determines the minimal effective dose of a gene vector to maximize therapeutic efficacy while minimizing adverse effects and immune responses.

37

Publications

1.8K

Citations

307

Authors

103

Institutions

Publications per year

2017–2026

21

Parents

Publications

37

Quantifying Adenovirus-Neutralizing Antibodies by Luciferase Transgene Detection: Addressing Preexisting Immunity to Vaccine and Gene Therapy Vectors

Mieke Sprangers, Wandena Lakhai, Wouter Koudstaal et al. · Journal of Clinical Microbiology · 2003 · 188 citations · Full text

, , +17

Influence of Vector Dose on Factor IX-Specific T and B Cell Responses in Muscle-Directed Gene Therapy

Roland W. Herzog, Paul Fields, Valder R. Arruda et al. · Human Gene Therapy · 2002 · 145 citations

, , +14

Efficacy and Safety of Long-term Prophylaxis in Severe Hemophilia A Dogs Following Liver Gene Therapy Using AAV Vectors

Denise E. Sabatino, Amy M. Lange, Ekaterina Altynova et al. · Molecular Therapy · 2010 · 119 citations · Full text

, , +13

rAAV2/5 gene-targeting to rods:dose-dependent efficiency and complications associated with different promoters

William A. Beltran, Sanford L. Boye, Sanford L. Boye et al. · Gene Therapy · 2010 · 105 citations · Full text

, , +14

AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice

Chady H. Hakim, Nalinda B. Wasala, Christopher E. Nelson et al. · JCI Insight · 2018 · 99 citations · Full text

, , +15

1–5 of 37

Authors

307

  1. JM
    James M. Wilson

    University of Pennsylvania, United States

    4 publications · 112 citations

    4

    h-index

  2. PB
    Peter Bell

    University of Pennsylvania, United States

    3 publications · 64 citations

    3

    h-index

  3. AS
    Arun Srivastava

    University of Florida, United States

    3 publications · 134 citations

    3

    h-index

  4. RW
    Roland W. Herzog

    University of Florida, United States

    3 publications · 198 citations

    3

    h-index

  5. DD
    Dongsheng Duan

    University of Missouri, United States

    2 publications · 180 citations

    2

    h-index

1–5 of 307

Institutions

103

  1. University of Pennsylvania

    Philadelphia, United States

    9 h-index

    49 publications

    2.5K citations

  2. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    4 h-index

    11 publications

    1.1K citations

  3. University of Florida

    Gainesville, United States

    4 h-index

    16 publications

    871 citations

  4. Medizinische Hochschule Hannover

    Hanover, Germany

    3 h-index

    21 publications

    922 citations

  5. Children's Hospital of Philadelphia

    Philadelphia, United States

    3 h-index

    11 publications

    1K citations

  6. University of Massachusetts Chan Medical School

    Worcester, United States

    2 h-index

    11 publications

    147 citations

  7. University of Oxford

    Oxford, United Kingdom

    2 h-index

    8 publications

    358 citations

  8. Applied Genetic Technologies (United States)

    Alachua, United States

    2 h-index

    11 publications

    260 citations

1–8 of 103

Venues

  1. 9

    h-index

  2. Human Gene Therapy

    6 publications · 400 citations

    6

    h-index

  3. Molecular Therapy

    3 publications · 204 citations

    3

    h-index

  4. Molecular Therapy — Nucleic Acids

    2 publications · 92 citations

    2

    h-index

  5. Gene Therapy

    2 publications · 160 citations

    2

    h-index

1–5