Concepedia

Two-stage Carcinogenesis

Two-Stage Carcinogenesis is a theoretical framework in cancer biology that posits tumor development proceeds through two sequential and mechanistically distinct phases—initiation and promotion—where irreversible genetic damage is followed by sustained cellular proliferation, thereby distinguishing it from models emphasizing gradual or stochastic accumulation of mutations.

453

Publications

24K

Citations

1.5K

Authors

383

Institutions

Publications per year

2017–2026

11

Variants

Two-stage Model Of Carcinogenesis

Parents

Publications

453

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

R A Weinberg · PubMed · 1989 · 952 citations

, , +14

Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter.

Masami Suganuma, Hirota Fujiki, Hiroko Suguri et al. · Proceedings of the National Academy of Sciences · 1988 · 601 citations · Full text

, , +13

A Two-stage Theory of Carcinogenesis in Relation to the Age Distribution of Human Cancer

P. Armitage, Ronald J. Doll · British Journal of Cancer · 1957 · 563 citations · Full text

, , +16

[Chemoprevention of cancer].

Hirota Fujiki · PubMed · 1986 · 527 citations

, , +16

Cocarcinogenic and Tumor-Promoting Agents in Tobacco Carcinogenesis2

Benjamin L. Van Duuren, B. M. Goldschmidt · JNCI Journal of the National Cancer Institute · 1976 · 346 citations

, , +15

1–5 of 453

Authors

1.5K

  1. HT
    Harukuni Tokuda

    Kyoto Prefectural University of Medicine, Japan

    40 publications · 2.5K citations

    32

    h-index

  2. HN
    Hoyoku Nishino

    Kyoto Prefectural University of Medicine, Japan

    31 publications · 1.9K citations

    26

    h-index

  3. TK
    Takao Konoshima

    Kyoto Pharmaceutical University, Japan

    23 publications · 1.8K citations

    23

    h-index

  4. KY
    Ken Yasukawa

    Nihon University, Japan

    22 publications · 1.2K citations

    17

    h-index

  5. HF
    Hirota Fujiki

    Saitama Cancer Center, Japan

    18 publications · 2.4K citations

    17

    h-index

1–5 of 1.5K

Institutions

383

  1. Kyoto Prefectural University of Medicine

    Kyoto, Japan

    32 h-index

    156 publications

    10.5K citations

  2. Kyoto Pharmaceutical University

    Kyoto, Japan

    22 h-index

    48 publications

    3.3K citations

  3. The University of Texas MD Anderson Cancer Center

    Houston, United States

    21 h-index

    137 publications

    9.2K citations

  4. National Institute of Health Sciences

    Tokyo, Japan

    18 h-index

    101 publications

    2.7K citations

  5. National Cancer Institute

    Bethesda, United States

    18 h-index

    59 publications

    5.2K citations

  6. Nihon University

    Tokyo, Japan

    17 h-index

    74 publications

    4.2K citations

  7. Nagoya City University

    Nagoya, Japan

    15 h-index

    67 publications

    3.8K citations

  8. German Cancer Research Center

    Heidelberg, Germany

    12 h-index

    43 publications

    1.1K citations

1–8 of 383

Venues

  1. PubMed

    Repository · 80 publications · 5.6K citations

    37

    h-index

  2. Carcinogenesis

    67 publications · 3.2K citations

    32

    h-index

  3. Cancer Letters

    27 publications · 928 citations

    20

    h-index

  4. Biological and Pharmaceutical Bulletin

    21 publications · 1.3K citations

    19

    h-index

  5. Cancer Research

    18 publications · 1.3K citations

    18

    h-index

1–5