Concepedia

Trem2 Genetics

TREM2 Genetics is a genetic research framework that investigates the role of variants in the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) gene in modulating neuroinflammatory processes and microglial function underlying susceptibility to neurodegenerative dementias.

249

Publications

34.4K

Citations

2.5K

Authors

701

Institutions

Publications per year

2017–2026

154

Parents

Publications

249

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Susanne Krasemann, Charlotte Madore, Ron Cialic et al. · Immunity · 2017 · 3K citations · Full text

, , +16

Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

Thorlákur Jónsson, Hreinn Stefánsson, Stacy Steinberg et al. · New England Journal of Medicine · 2012 · 2.6K citations · Full text

, , +17

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

Yingyue Zhou, Wilbur M. Song, Prabhakar S. Andhey et al. · Nature Medicine · 2020 · 1.2K citations · Full text

, , +16

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Rebecca Sims, Sven J. van der Lee, Adam C. Naj et al. · Nature Genetics · 2017 · 1.1K citations · Full text

, , +12

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

Gernot Kleinberger, Yoshinori Yamanishi, Marc Suárez‐Calvet et al. · Science Translational Medicine · 2014 · 837 citations

, , +13

1–5 of 249

Authors

2.5K

  1. MC
    Marco Colonna

    Washington University in St. Louis, United States

    18 publications · 6.6K citations

    17

    h-index

  2. CC
    Carlos Cruchaga

    Washington University in St. Louis, United States

    17 publications · 3.8K citations

    16

    h-index

  3. JH
    John Hardy

    University College London, United Kingdom

    16 publications · 4K citations

    15

    h-index

  4. DM
    David M. Holtzman

    Washington University in St. Louis, United States

    11 publications · 6.2K citations

    11

    h-index

  5. CH
    Christian Haass

    Ludwig-Maximilians-Universität München, Germany

    10 publications · 5.8K citations

    10

    h-index

1–5 of 2.5K

Institutions

701

  1. Washington University in St. Louis

    St Louis, United States

    33 h-index

    291 publications

    71.3K citations

  2. University College London

    London, United Kingdom

    22 h-index

    156 publications

    34K citations

  3. Hope Center for Neurological Disorders

    St Louis, United States

    18 h-index

    119 publications

    27.8K citations

  4. German Center for Neurodegenerative Diseases

    Bonn, Germany

    16 h-index

    77 publications

    29.7K citations

  5. Ludwig-Maximilians-Universität München

    Munich, Germany

    15 h-index

    100 publications

    26.8K citations

  6. Indiana University – Purdue University Indianapolis

    Indianapolis, United States

    14 h-index

    97 publications

    26.2K citations

  7. University of California, San Francisco

    San Francisco, United States

    13 h-index

    53 publications

    18.5K citations

  8. UK Dementia Research Institute

    London, United Kingdom

    13 h-index

    52 publications

    5.6K citations

1–8 of 701

Venues

  1. Neurobiology of Aging

    21 publications · 1.9K citations

    19

    h-index

  2. Molecular Neurodegeneration

    MN · 13 publications · 2.3K citations

    13

    h-index

  3. Scientific Reports

    9 publications · 423 citations

    9

    h-index

  4. Journal of Alzheimer s Disease

    JAD · 8 publications · 511 citations

    8

    h-index

  5. Neurobiology of Disease

    6 publications · 297 citations

    6

    h-index

1–5