TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

Gernot Kleinberger, Yoshinori Yamanishi, Marc Suárez‐Calvet, +29

Science Translational Medicine

TREM2 sustains microglial expansion during aging and response to demyelination

Pietro Luigi Poliani, Yaming Wang, Elena Fontana, +4

Journal of Clinical Investigation

ImmunologyImmune RegulationSynaptic SignalingMicroglia ContributeSocial Sciences +16

Trogocytosis of peptide–MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils

Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, +3

Proceedings of the National Academy of Sciences

Immune ActivationTh2 Cell DifferentiationInnate Immune SystemImmunologyImmunologic Mechanism +18

Basophils trigger emphysema development in a murine model of COPD through IL-4–mediated generation of MMP-12–producing macrophages

Sho Shibata, Kensuke Miyake, Tomoya Tateishi, +5

Proceedings of the National Academy of Sciences

AsthmaInflammatory Lung DiseaseLung InflammationImmunologyInnate Immunity +21

The Receptor LMIR3 Negatively Regulates Mast Cell Activation and Allergic Responses by Binding to Extracellular Ceramide

Kumi Izawa, Yoshinori Yamanishi, Akie Maehara, +13

Immunity

InflammationMolecular PhysiologyAllergySignal TransductionExtracellular Ceramide +10

TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury

Yoshinori Yamanishi, Jiro Kitaura, Kumi Izawa, +14

The Journal of Experimental Medicine

Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation

Toshihiro Matsukawa, Kumi Izawa, Masamichi Isobe, +8

Gut

Involvement of P-type calcium channels in high potassium-elicited release of neurotransmitters from rat brain slices

M. Kimura, Yoshinori Yamanishi, Takahisa Hanada, +5

Neuroscience

NeurophysiologyHigh Potassium-elicited ReleaseSynaptic TransmissionPhysiologyP-type Calcium Channels +11

Functional Analysis of Activating Receptor LMIR4 as a Counterpart of Inhibitory Receptor LMIR3

Kumi Izawa, Jiro Kitaura, Yoshinori Yamanishi, +10

Journal of Biological Chemistry

An Activating and Inhibitory Signal from an Inhibitory Receptor LMIR3/CLM-1: LMIR3 Augments Lipopolysaccharide Response through Association with FcRγ in Mast Cells

Kumi Izawa, Jiro Kitaura, Yoshinori Yamanishi, +9

The Journal of Immunology

Mast Cell DisorderImmunologyImmune RegulationImmunologic MechanismImmune System +17