Concepedia

Thermal Proteome Profiling

Thermal Proteome Profiling is a functional proteomics method that systematically identifies changes in protein thermal stability across the proteome upon perturbation, enabling the detection of drug targets, protein interactions, and functional states by measuring differential thermal denaturation profiles.

92

Publications

6.4K

Citations

685

Authors

219

Institutions

Publications per year

2017–2026

82

Variants

Tpp

Parents

Publications

92

Tracking cancer drugs in living cells by thermal profiling of the proteome

Mikhail M. Savitski, Friedrich Reinhard, Holger Franken et al. · Science · 2014 · 1.2K citations

, , +17

Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry

Holger Franken, Toby Mathieson, Dorothee Childs et al. · Nature Protocols · 2015 · 708 citations

, , +17

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins

Friedrich Reinhard, Dirk Eberhard, Thilo Werner et al. · Nature Methods · 2015 · 319 citations

, , +14

Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP

Sindhuja Sridharan, Nils Kurzawa, Thilo Werner et al. · Nature Communications · 2019 · 276 citations · Full text

, , +17

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling

K. Huber, K. Olek, André C. Müller et al. · Nature Methods · 2015 · 220 citations · Full text

, , +16

1–5 of 92

Authors

685

  1. MM
    Mikhail M. Savitski

    European Molecular Biology Laboratory, Germany

    15 publications · 3.2K citations

    14

    h-index

  2. NK
    Nils Kurzawa

    Heidelberg University, Germany

    8 publications · 817 citations

    8

    h-index

  3. MB
    Marcus Bantscheff

    GlaxoSmithKline (Germany), Germany

    8 publications · 2.5K citations

    8

    h-index

  4. AM
    André Mateus

    European Molecular Biology Laboratory, Germany

    6 publications · 360 citations

    6

    h-index

  5. FS
    Frank Stein

    European Molecular Biology Laboratory, Germany

    5 publications · 337 citations

    5

    h-index

1–5 of 685

Institutions

219

  1. European Molecular Biology Laboratory

    Heidelberg, Germany

    11 h-index

    67 publications

    6.5K citations

  2. Heidelberg University

    Heidelberg, Germany

    11 h-index

    19 publications

    6K citations

  3. Karolinska Institutet

    Stockholm, Sweden

    8 h-index

    53 publications

    10.7K citations

  4. GlaxoSmithKline (Germany)

    Hamburg, Germany

    8 h-index

    46 publications

    27.1K citations

  5. European Molecular Biology Organization

    Heidelberg, Germany

    8 h-index

    10 publications

    1K citations

  6. Science for Life Laboratory

    Stockholm, Sweden

    6 h-index

    31 publications

    1.7K citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    5 h-index

    8 publications

    380 citations

  8. University of Dundee

    Dundee, United Kingdom

    5 h-index

    54 publications

    1.9K citations

1–8 of 219

Venues

  1. Analytical Chemistry

    6 publications · 165 citations

    6

    h-index

  2. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 6 publications · 164 citations

    6

    h-index

  3. Nature Methods

    4 publications · 776 citations

    4

    h-index

  4. ACS Chemical Biology

    4 publications · 113 citations

    4

    h-index

  5. Journal of Proteome Research

    JPR · 3 publications · 117 citations

    3

    h-index

1–5