Concepedia

Tau Fragmentation

Tau Fragmentation is a pathological process characterized by the proteolytic cleavage of the microtubule-associated protein tau into smaller, dysfunctional fragments, distinguishing it from other tau modifications by its irreversible disruption of tau's structural and functional integrity in neurodegenerative diseases.

136

Publications

13.4K

Citations

849

Authors

281

Institutions

Publications per year

2017–2026

44

Parents

Publications

136

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

Michel Goedert, Maria Grazia Spillantini, Ross Jakes et al. · Neuron · 1989 · 2.5K citations

, , +16

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

Yipeng Wang, Marta Martínez‐Vicente, Ulrike Krüger et al. · Human Molecular Genetics · 2009 · 608 citations · Full text

, , +17

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

Zhentao Zhang, Mingke Song, Xia Liu et al. · Nature Medicine · 2014 · 487 citations · Full text

, , +13

Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology

Inge Grundke‐Iqbal, Khalid Iqbal, Y-C Tung et al. · Alzheimer Disease & Associated Disorders · 1987 · 417 citations

, , +16

Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice

Walter J. Brecht, Faith M. Harris, Shengjun Chang et al. · Journal of Neuroscience · 2004 · 401 citations · Full text

, , +17

1–5 of 136

Authors

849

  1. KY
    Keqiang Ye

    Emory University, United States

    6 publications · 978 citations

    6

    h-index

  2. AF
    Adriana Ferreira

    Northwestern University, United States

    5 publications · 542 citations

    5

    h-index

  3. MN
    Michal Novák

    Slovak Academy of Sciences, Slovakia

    5 publications · 548 citations

    5

    h-index

  4. AC
    Antonino Cattaneo

    European Brain Research Institute, Italy

    5 publications · 617 citations

    5

    h-index

  5. GB
    Gunnar Brinkmalm

    University of Gothenburg, Sweden

    3 publications · 295 citations

    3

    h-index

1–5 of 849

Institutions

281

  1. Northwestern University

    Evanston, United States

    7 h-index

    28 publications

    2.2K citations

  2. Emory University

    Atlanta, United States

    6 h-index

    40 publications

    7.9K citations

  3. Huazhong University of Science and Technology

    Wuhan, China

    5 h-index

    18 publications

    1.6K citations

  4. UK Dementia Research Institute

    London, United Kingdom

    5 h-index

    7 publications

    565 citations

  5. Tongji Hospital

    Wuhan, China

    4 h-index

    17 publications

    1.4K citations

  6. Icahn School of Medicine at Mount Sinai

    New York, United States

    4 h-index

    14 publications

    1.2K citations

  7. Wuhan University

    Wuhan, China

    4 h-index

    15 publications

    894 citations

  8. Scuola Internazionale Superiore di Studi Avanzati

    Trieste, Italy

    4 h-index

    10 publications

    1.2K citations

1–8 of 281

Venues

  1. Journal of Alzheimer s Disease

    JAD · 13 publications · 661 citations

    12

    h-index

  2. Neurobiology of Aging

    6 publications · 423 citations

    6

    h-index

  3. Neurobiology of Disease

    6 publications · 825 citations

    6

    h-index

  4. Journal of Neuroscience

    5 publications · 1.2K citations

    5

    h-index

  5. Neuroscience

    5 publications · 243 citations

    5

    h-index

1–5