Concepedia

Targeted Library Design

Targeted Library Design is a systematic approach in chemical library design that focuses on the deliberate selection and optimization of compounds directed toward specific biological targets or pathways, distinguished from general library design by its emphasis on target relevance and molecular specificity.

46

Publications

2.5K

Citations

286

Authors

95

Institutions

Publications per year

2017–2026

13

Parents

Publications

46

High-throughput discovery of organic cages and catenanes using computational screening fused with robotic synthesis

Rebecca L. Greenaway, Valentina Santolini, Michael J. Bennison et al. · Nature Communications · 2018 · 217 citations · Full text

, , +13

Grand Challenge Commentary: Accessing new chemical space for 'undruggable' targets

Sivaraman Dandapani, Lisa A. Marcaurelle · Nature Chemical Biology · 2010 · 209 citations

, , +14

Nanomolar Potency and Metabolically Stable Inhibitors of Kidney Urea Transporter UT-B

Marc O. Anderson, Jicheng Zhang, Yan Liu et al. · Journal of Medicinal Chemistry · 2012 · 147 citations · Full text

, , +16

XCMS-MRM and METLIN-MRM: a cloud library and public resource for targeted analysis of small molecules

Xavier Domingo-Almenara, J. Rafael Montenegro-Burke, Julijana Ivanišević et al. · Nature Methods · 2018 · 133 citations

, , +17

Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria

K. C. Nicolaou, Robert Hughes, Suk Young Cho et al. · Angewandte Chemie International Edition · 2000 · 131 citations

, , +17

1–5 of 46

Authors

286

  1. NW
    Nicolas Winssinger

    University of Geneva, Switzerland

    2 publications · 256 citations

    2

    h-index

  2. MB
    Matthew B. Francis

    University of California, Berkeley, United States

    2 publications · 50 citations

    2

    h-index

  3. WZ
    Weifan Zheng

    University of North Carolina at Chapel Hill, United States

    2 publications · 166 citations

    2

    h-index

  4. HL
    Harald Labischinski

    Robert Koch Institute, Germany

    2 publications · 256 citations

    2

    h-index

  5. DB
    Daniel Bader

    Queen Mary University of London, United Kingdom

    2 publications · 50 citations

    2

    h-index

1–5 of 286

Institutions

95

  1. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    6 h-index

    20 publications

    781 citations

  2. University of California, Berkeley

    Berkeley, United States

    3 h-index

    7 publications

    295 citations

  3. Scripps Research Institute

    San Diego, United States

    3 h-index

    18 publications

    2.3K citations

  4. University of Edinburgh

    Edinburgh, United Kingdom

    2 h-index

    4 publications

    105 citations

  5. Institute for Research in Immunology and Cancer

    Montreal, Canada

    2 h-index

    22 publications

    812 citations

  6. Goethe University Frankfurt

    Frankfurt am Main, Germany

    2 h-index

    6 publications

    75 citations

  7. University of Liverpool

    Liverpool, United Kingdom

    2 h-index

    14 publications

    2.8K citations

  8. Imperial College London

    London, United Kingdom

    2 h-index

    7 publications

    1.2K citations

1–8 of 95

Venues

  1. Journal of Medicinal Chemistry

    3 publications · 263 citations

    3

    h-index

  2. ChemMedChem

    3 publications · 59 citations

    3

    h-index

  3. 3

    h-index

  4. Journal of Molecular Graphics and Modelling

    2 publications · 60 citations

    2

    h-index

  5. 2

    h-index

1–5