Concepedia

Target Selectivity Prediction

Target Selectivity Prediction is a computational method that identifies the propensity of a drug to preferentially interact with a specific biological target over structurally or functionally related off-targets, thereby quantifying the specificity of drug-target interactions within the context of polypharmacology.

61

Publications

5.5K

Citations

349

Authors

145

Institutions

Publications per year

2017–2026

26

Parents

Publications

61

Selective Photothermolysis: Precise Microsurgery by Selective Absorption of Pulsed Radiation

R. Rox Anderson, John A. Parrish · Science · 1983 · 3.4K citations

, , +17

Polypharmacology Browser PPB2: Target Prediction Combining Nearest Neighbors with Machine Learning

Mahendra Awale, Jean‐Louis Reymond · Journal of Chemical Information and Modeling · 2018 · 172 citations · Full text

, , +17

Identifying Drug-Target Selectivity of Small-Molecule CRM1/XPO1 Inhibitors by CRISPR/Cas9 Genome Editing

Jasper E. Neggers, Thomas Vercruysse, Maarten Jacquemyn et al. · Chemistry & Biology · 2015 · 135 citations

, , +16

Novel Synthetic Biscoumarins Target Tumor Necrosis Factor-α in Hepatocellular Carcinoma in Vitro and in Vivo

Hosadurga K. Keerthy, Chakrabhavi Dhananjaya Mohan, Kodappully Sivaraman Siveen et al. · Journal of Biological Chemistry · 2014 · 75 citations · Full text

, , +14

Small molecule detection with aptamer based lateral flow assays: Applying aptamer-C-reactive protein cross-recognition for ampicillin detection

Lars Kaiser, Julia Weisser, Matthias Kohl et al. · Scientific Reports · 2018 · 71 citations · Full text

, , +17

1–5 of 61

Authors

349

  1. AB
    Andreas Bender

    University of Cambridge, United Kingdom

    4 publications · 175 citations

    4

    h-index

  2. GS
    Gisbert Schneider

    ETH Zurich, Switzerland

    3 publications · 63 citations

    3

    h-index

  3. JB
    Jürgen Bajorath

    University of Bonn, Germany

    2 publications · 67 citations

    2

    h-index

  4. PS
    Petra Schneider

    ETH Zurich, Switzerland

    2 publications · 43 citations

    2

    h-index

  5. GJ
    Gerard J. P. van Westen

    Centre for Human Drug Research, Netherlands

    2 publications · 43 citations

    2

    h-index

1–5 of 349

Institutions

145

  1. University of Cambridge

    Cambridge, United Kingdom

    5 h-index

    17 publications

    782 citations

  2. ETH Zurich

    Zurich, Switzerland

    3 h-index

    14 publications

    213 citations

  3. AstraZeneca (Sweden)

    Södertälje, Sweden

    3 h-index

    5 publications

    139 citations

  4. National University of Singapore

    Singapore, Singapore

    3 h-index

    7 publications

    325 citations

  5. Fraunhofer Institute for Cell Therapy and Immunology

    Leipzig, Germany

    2 h-index

    9 publications

    239 citations

  6. University of Minnesota

    Minneapolis, United States

    2 h-index

    4 publications

    192 citations

  7. Leiden University

    Leiden, The Netherlands

    2 h-index

    10 publications

    210 citations

  8. Chongqing University of Posts and Telecommunications

    Chongqing, China

    2 h-index

    6 publications

    146 citations

1–8 of 145

Venues

  1. Journal of Chemical Information and Modeling

    JCIM · 8 publications · 431 citations

    8

    h-index

  2. Journal of Medicinal Chemistry

    6 publications · 268 citations

    6

    h-index

  3. Bioorganic & Medicinal Chemistry

    2 publications · 56 citations

    2

    h-index

  4. Scientific Reports

    2 publications · 95 citations

    2

    h-index

  5. ACS Medicinal Chemistry Letters

    2 publications · 41 citations

    2

    h-index

1–5