Concepedia

Target Selectivity Analysis

Target Selectivity Analysis is a computational method in drug target informatics that identifies and evaluates the specificity of a drug candidate for its intended biological target relative to off-target interactions across the proteome.

74

Publications

5.5K

Citations

482

Authors

142

Institutions

Publications per year

2017–2026

21

Parents

Publications

74

PubChem: a public information system for analyzing bioactivities of small molecules

Y. Wang, J. Xiao, Tuğba Önal-Süzek et al. · Nucleic Acids Research · 2009 · 1.5K citations · Full text

, , +17

Making Sense of Large-Scale Kinase Inhibitor Bioactivity Data Sets: A Comparative and Integrative Analysis

Jing Tang, Agnieszka Szwajda, Sushil Kumar Shakyawar et al. · Journal of Chemical Information and Modeling · 2014 · 629 citations

, , +17

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

Bryan Lanning, Landon R. Whitby, Melissa M. Dix et al. · Nature Chemical Biology · 2014 · 363 citations · Full text

, , +15

Cytotoxicity, Post-Treatment Recovery, and Selectivity Analysis of Naturally Occurring Podophyllotoxins from Bursera fagaroides var. fagaroides on Breast Cancer Cell Lines

Omar Aristeo Peña-Morán, María Villarreal, Laura Álvarez et al. · Molecules · 2016 · 243 citations · Full text

, , +13

GRID/CPCA:  A New Computational Tool To Design Selective Ligands

Mika A. Kastenholz, Manuel Pastor, Gabriele Cruciani et al. · Journal of Medicinal Chemistry · 2000 · 184 citations · Full text

, , +16

1–5 of 74

Authors

482

  1. JB
    Jürgen Bajorath

    University of Bonn, Germany

    5 publications · 140 citations

    5

    h-index

  2. YH
    Ye Hu

    University of Bonn, Germany

    3 publications · 68 citations

    3

    h-index

  3. MP
    Marc P. Baggelaar

    Leiden University, Netherlands

    2 publications · 41 citations

    2

    h-index

  4. GJ
    Gerard J. P. van Westen

    Centre for Human Drug Research, Netherlands

    2 publications · 85 citations

    2

    h-index

  5. DF
    Domenico Fazio

    European Brain Research Institute, Italy

    2 publications · 41 citations

    2

    h-index

1–5 of 482

Institutions

142

  1. University of Bonn

    Bonn, Germany

    5 h-index

    12 publications

    368 citations

  2. Leiden University

    Leiden, The Netherlands

    3 h-index

    16 publications

    342 citations

  3. Pfizer (United States)

    New York, United States

    3 h-index

    35 publications

    4.6K citations

  4. National Institutes of Health

    Bethesda, United States

    3 h-index

    11 publications

    9K citations

  5. European Brain Research Institute

    Rome, Italy

    2 h-index

    2 publications

    41 citations

  6. Institute for Molecular Medicine Finland

    Helsinki, Finland

    2 h-index

    10 publications

    4.5K citations

  7. Università Campus Bio-Medico

    Rome, Italy

    2 h-index

    2 publications

    41 citations

  8. University of Copenhagen

    Copenhagen, Denmark

    2 h-index

    11 publications

    278 citations

1–8 of 142

Venues

  1. Journal of Medicinal Chemistry

    6 publications · 489 citations

    6

    h-index

  2. ACS Medicinal Chemistry Letters

    5 publications · 114 citations

    5

    h-index

  3. ACS Chemical Biology

    4 publications · 103 citations

    4

    h-index

  4. Journal of Chemical Information and Modeling

    JCIM · 4 publications · 718 citations

    4

    h-index

  5. Chemical Biology & Drug Design

    3 publications · 84 citations

    3

    h-index

1–5