Concepedia

Target Deconvolution Algorithms

Target Deconvolution Algorithms is a computational methodology that systematically infers the molecular targets of bioactive compounds by reversing phenotypic responses through algorithmic integration of omics data, chemical profiles, and interaction networks.

36

Publications

2.7K

Citations

257

Authors

116

Institutions

Publications per year

2017–2026

19

Parents

Publications

36

The target landscape of clinical kinase drugs

Susan Klaeger, Stephanie Heinzlmeir, Mathias Wilhelm et al. · Science · 2017 · 871 citations · Full text

, , +15

Prediction of Biological Targets for Compounds Using Multiple-Category Bayesian Models Trained on Chemogenomics Databases

Nidhi Nidhi, Meir Glick, John W. Davies et al. · Journal of Chemical Information and Modeling · 2006 · 343 citations

, , +15

A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes

Ilaria Piazza, Nigel Beaton, Roland Bruderer et al. · Nature Communications · 2020 · 180 citations · Full text

, , +14

Exploiting polypharmacology for drug target deconvolution

Taranjit S. Gujral, Leonid Peshkin, Marc W. Kirschner · Proceedings of the National Academy of Sciences · 2014 · 113 citations · Full text

, , +16

Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

Severin Lechner, Martin Ian P. Malgapo, Christian Grätz et al. · Nature Chemical Biology · 2022 · 112 citations · Full text

, , +9

1–5 of 36

Authors

257

  1. RA
    Roman A. Zubarev

    Karolinska Institutet, Sweden

    4 publications · 225 citations

    4

    h-index

  2. RE
    Richard E. Higgs

    Eli Lilly (United States), United States

    3 publications · 69 citations

    3

    h-index

  3. BK
    Bernhard Küster

    Technical University of Munich, Germany

    3 publications · 1K citations

    3

    h-index

  4. GM
    Guillaume Médard

    Technical University of Munich, Germany

    3 publications · 1K citations

    3

    h-index

  5. JE
    John E. Hale

    Eli Lilly (United States), United States

    3 publications · 69 citations

    3

    h-index

1–5 of 257

Institutions

116

  1. Karolinska Institutet

    Stockholm, Sweden

    4 h-index

    16 publications

    984 citations

  2. Technical University of Munich

    Munich, Germany

    3 h-index

    45 publications

    18.9K citations

  3. Science for Life Laboratory

    Stockholm, Sweden

    3 h-index

    11 publications

    684 citations

  4. Eli Lilly (United States)

    Indianapolis, United States

    3 h-index

    12 publications

    255 citations

  5. Heidelberg University

    Heidelberg, Germany

    3 h-index

    20 publications

    14.2K citations

  6. Deutsches Konsortium für Translationale Krebsforschung

    Heidelberg, Germany

    3 h-index

    19 publications

    14.9K citations

  7. German Cancer Research Center

    Heidelberg, Germany

    3 h-index

    22 publications

    15.1K citations

  8. Novartis (China)

    Beijing, China

    2 h-index

    2 publications

    110 citations

1–8 of 116

Venues

  1. Journal of Chemical Information and Modeling

    JCIM · 3 publications · 393 citations

    3

    h-index

  2. Methods in molecular biology

    Book series · 3 publications · 83 citations

    3

    h-index

  3. Journal of Proteome Research

    JPR · 3 publications · 68 citations

    3

    h-index

  4. Nature Communications

    3 publications · 291 citations

    3

    h-index

  5. SLAS DISCOVERY

    2 publications · 65 citations

    2

    h-index

1–5