The target landscape of clinical kinase drugs

Susan Klaeger, Stephanie Heinzlmeir, Mathias Wilhelm, +43

Science

Tumor BiologyProteomicsdb DatabaseDrug TargetOncologyTarget Landscape +12

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

Christina J. Groß, Ritu Mishra, Katharina S. Schneider, +24

Immunity

InflammationSignal TransductionSignaling PathwayMitochondrial FunctionNatural Sciences +9

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

Katharina S. Schneider, Christina J. Groß, Roland F. Dreier, +14

Cell Reports

DMSO enhances electrospray response, boosting sensitivity of proteomic experiments

Hannes Hahne, Fiona Pachl, Benjamin Ruprecht, +7

Nature Methods

Proteomic TechnologyBiochemistryMedicineNatural SciencesBioanalysis +4

Optimized Chemical Proteomics Assay for Kinase Inhibitor Profiling

Guillaume Médard, Fiona Pachl, Benjamin Ruprecht, +12

Journal of Proteome Research

ProteomeTools: Systematic Characterization of 21 Post-translational Protein Modifications by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Using Synthetic Peptides

Daniel P. Zolg, Mathias Wilhelm, Tobias Schmidt, +7

Molecular & Cellular Proteomics

Modified PeptidesBiological Mass SpectrometryMolecular BiologyUsing Synthetic PeptidesPeptide Science +20

<i>N</i>-Heterocyclic carbenes on close-packed coinage metal surfaces: bis-carbene metal adatom bonding scheme of monolayer films on Au, Ag and Cu

Jiang Li, Bodong Zhang, Guillaume Médard, +7

Chemical Science

Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening

Daniela M. Arduíno, Jennifer Wettmarshausen, Horia Vais, +14

Molecular Cell

Systematic IdentificationEngineeringChemical AnalysisBioelectronicsMass Spectrometry +6

Comprehensive and Reproducible Phosphopeptide Enrichment Using Iron Immobilized Metal Ion Affinity Chromatography (Fe-IMAC) Columns

Benjamin Ruprecht, Heiner Koch, Guillaume Médard, +3

Molecular & Cellular Proteomics

Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

Severin Lechner, Martin Ian P. Malgapo, Christian Grätz, +22

Nature Chemical Biology

Drug TargetBiochemistryMedicineMechanism Of ActionTarget Deconvolution +3