Concepedia

Substrate Binding Pocket Stabilization

Substrate Binding Pocket Stabilization is a protein engineering strategy that involves the structural reinforcement of the active site region in an enzyme to maintain its functional conformation under thermal stress, thereby enhancing catalytic efficiency and thermostability.

71

Publications

2.4K

Citations

458

Authors

161

Institutions

Publications per year

2017–2026

30

Parents

Publications

71

Reduced activity of the hypertension‐associated Lys528Arg mutant of human adipocyte‐derived leucine aminopeptidase (A‐LAP)/ER‐aminopeptidase‐1

Yoshikuni Goto, Akira Hattori, Yasuhiro Ishii et al. · FEBS Letters · 2006 · 114 citations · Full text

, , +10

Structural Basis for the Recognition of the FapydG Lesion (2,6-Diamino-4-hydroxy-5-formamidopyrimidine) by Formamidopyrimidine-DNA Glycosylase

F Coste, Matthias Ober, Thomas Carell et al. · Journal of Biological Chemistry · 2004 · 107 citations · Full text

, , +13

Molecular Insights into the Enhanced Performance of EKylated PETase Toward PET Degradation

Kun Chen, Yang Hu, Xiaoyan Dong et al. · ACS Catalysis · 2021 · 106 citations

, , +17

Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization

Gerlis von Haugwitz, Xu Han, Lara Pfaff et al. · ACS Catalysis · 2022 · 94 citations · Full text

, , +16

Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense

Annette Fischer, Kelly S. Harrison, Yesid A. Ramírez et al. · eLife · 2017 · 84 citations · Full text

, , +13

1–5 of 71

Authors

458

  1. TH
    Thomas Haertlé

    Biopolymères Interactions Assemblages, France

    2 publications · 32 citations

    2

    h-index

  2. HW
    Hongli Wei

    Chinese Academy of Sciences, China

    2 publications · 152 citations

    2

    h-index

  3. JC
    Jean‐Marc Chobert

    Biopolymères Interactions Assemblages, France

    2 publications · 32 citations

    2

    h-index

  4. WL
    Weidong Liu

    Chinese Academy of Sciences, China

    2 publications · 152 citations

    2

    h-index

  5. LB
    Loı̈c Briand

    Bioénergétique et Ingénierie des Protéines, France

    2 publications · 32 citations

    2

    h-index

1–5 of 458

Institutions

161

  1. Chinese Academy of Sciences

    Beijing, China

    8 h-index

    35 publications

    1.5K citations

  2. Jiangnan University

    Wuxi, China

    6 h-index

    37 publications

    638 citations

  3. State Key Laboratory of Food Science and Technology

    Wuxi, China

    3 h-index

    15 publications

    293 citations

  4. Tianjin Institute of Industrial Biotechnology

    Tianjin, China

    3 h-index

    19 publications

    1.2K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    9 publications

    555 citations

  6. Tianjin University

    Tianjin, China

    2 h-index

    5 publications

    446 citations

  7. University of Würzburg

    Würzburg, Germany

    2 h-index

    12 publications

    764 citations

  8. Institut National de la Recherche Agronomique du Niger

    Niamey, Niger

    2 h-index

    2 publications

    32 citations

1–8 of 161

Venues

  1. ACS Catalysis

    6 publications · 396 citations

    6

    h-index

  2. Journal of Biological Chemistry

    JBC · 5 publications · 277 citations

    5

    h-index

  3. FEBS Letters

    4 publications · 165 citations

    4

    h-index

  4. MedChemComm

    2 publications · 33 citations

    2

    h-index

  5. 2

    h-index

1–5