Subclonal Expansion is a biological process in which a distinct subpopulation of genetically related cancer cells, derived from a common ancestral clone, proliferates disproportionately within a tumor due to selective pressures such as therapy, thereby contributing to therapy-induced heterogeneity and clonal evolution.
40
Publications
5.6K
Citations
864
Authors
264
Institutions
Publications per year
2017–2026
30
Publications
40
Age-related mutations associated with clonal hematopoietic expansion and malignancies
Mingchao Xie, Charles Lu, Jiayin Wang et al. · Nature Medicine · 2014 · 1.9K citations · Full text
Medicine, Genetics, Hematology +14
Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes
Stefan C. Dentro, Ignaty Leshchiner, Kerstin Haase et al. · Cell · 2021 · 557 citations · Full text
Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer
Matthew Hong, Geoff Macintyre, David C. Wedge et al. · Nature Communications · 2015 · 376 citations · Full text
Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts
Jeffrey J. Quinn, Matthew G. Jones, Ross A. Okimoto et al. · Science · 2021 · 315 citations · Full text
Medicine, Cancer Biology, Oncology +17
Breast tumours maintain a reservoir of subclonal diversity during expansion
Darlan Conterno Minussi, Michael D. Nicholson, Hanghui Ye et al. · Nature · 2021 · 288 citations · Full text
Medicine, Cancer Biology, Oncology +14
1–5 of 40
Authors
864
- PV
7
h-index
- DC
6
h-index
- GM
4
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- MC
4
h-index
- YJ
4
h-index
1–5 of 864
Institutions
264
Wellcome Sanger Institute
Cambridge, United Kingdom
6 h-index
56 publications
11.6K citations
The Francis Crick Institute
London, United Kingdom
5 h-index
92 publications
24.5K citations
University College London
London, United Kingdom
5 h-index
148 publications
33.3K citations
University of Cambridge
Cambridge, United Kingdom
5 h-index
30 publications
8.5K citations
Harvard University
Cambridge, United States
5 h-index
14 publications
2.5K citations
Cancer Research UK
London, United Kingdom
5 h-index
90 publications
24.2K citations
The University of Melbourne
Melbourne, Australia
5 h-index
25 publications
7.6K citations
Institute of Cancer Research
London, United Kingdom
5 h-index
43 publications
4.6K citations
1–8 of 264
Venues
- Nature Communications
6 publications · 770 citations
6
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- bioRxiv (Cold Spring Harbor Laboratory)
Repository · 4 publications · 174 citations
4
h-index
- International Journal of Cancer
3 publications · 73 citations
3
h-index
- Nature
3 publications · 706 citations
3
h-index
- Leukemia
2 publications · 208 citations
2
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1–5