Mutational landscape and significance across 12 major cancer types

Cyriac Kandoth, Michael D. McLellan, Fabio Vandin, +16

Nature

Age-related mutations associated with clonal hematopoietic expansion and malignancies

Mingchao Xie, Charles Lu, Jiayin Wang, +17

Nature Medicine

Hematological MalignancyAge-related MutationsHematologyPathologyMyeloid Neoplasia

MSIsensor: microsatellite instability detection using paired tumor-normal sequence data

Beifang Niu, Kai Ye, Qunyuan Zhang, +5

Bioinformatics

Patterns and functional implications of rare germline variants across 12 cancer types

Charles Lu, Mingchao Xie, Michael C. Wendl, +40

Nature Communications

Integrated analysis of germline and somatic variants in ovarian cancer

Krishna Kanchi, Kimberly Johnson, Charles Lu, +21

Nature Communications

Somatic VariantTumor HeterogeneityMedicineGynecologyPathology +4

DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape

Mingchao Xie, Chibo Hong, Bo Zhang, +24

Nature Genetics

Comparative Epigenomic Annotation of Regulatory DNA

Shu Dong XIAO, Dan Xie, Xiaoyi Cao, +9

Cell

Functional GenomicsGene Sequence AnnotationGeneticsComparative Epigenomic AnnotationEpigenomics +5

Estimating absolute methylation levels at single-CpG resolution from methylation enrichment and restriction enzyme sequencing methods

Michael Stevens, Jeffrey B. Cheng, Daofeng Li, +8

Genome Research

Absolute Methylation LevelsGeneticsDna MethylationEpigenetic ChangeGenomics +19

Systematic discovery of complex insertions and deletions in human cancers

Kai Ye, Jiayin Wang, Reyka G. Jayasinghe, +17

Nature Medicine

Tumor HeterogeneitySystematic DiscoveryMedicinePathologyCancer Genomics +5

Divergent viral presentation among human tumors and adjacent normal tissues

Song Cao, Michael C. Wendl, Matthew A. Wyczalkowski, +14

Scientific Reports