Concepedia

Spatial Mutational Signatures

Spatial Mutational Signatures is a computational framework that identifies and characterizes distinct patterns of somatic mutations across spatially resolved regions within tumors, integrating genomic data with spatial architecture to infer mutational processes operative in specific tissue microenvironments.

23

Publications

2.7K

Citations

459

Authors

205

Institutions

Publications per year

2017–2026

15

Parents

Publications

23

Mutational landscape and clonal architecture in grade II and III gliomas

Hiromichi Suzuki, Kosuke Aoki, Kenichi Chiba et al. · Nature Genetics · 2015 · 847 citations

, , +17

Spatial genomic heterogeneity within localized, multifocal prostate cancer

Paul C. Boutros, Michael Fraser, Nicholas J. Harding et al. · Nature Genetics · 2015 · 489 citations · Full text

, , +14

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

Hamid Nikbakht, Eshini Panditharatna, Leonie G. Mikael et al. · Nature Communications · 2016 · 262 citations · Full text

, , +15

The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location

Ilon Liu, Li Jiang, Erik Samuelsson et al. · Nature Genetics · 2022 · 193 citations · Full text

, , +17

Geographic and age variations in mutational processes in colorectal cancer

Marcos Díaz‐Gay, Wellington dos Santos, Sarah Moody et al. · Nature · 2025 · 123 citations · Full text

, , +16

1–5 of 23

Authors

459

  1. KL
    Keith L. Ligon

    Dana-Farber Cancer Institute, United States

    2 publications · 455 citations

    2

    h-index

  2. EP
    Eshini Panditharatna

    Neurological Surgery, United States

    2 publications · 455 citations

    2

    h-index

  3. DN
    Donna Neuberg

    Dana-Farber Cancer Institute, United States

    1 publications · 59 citations

    1

    h-index

  4. TL
    Tom L. Blundell

    University of Cambridge, United Kingdom

    1 publications · 17 citations

    1

    h-index

  5. PR
    Philip Rosenstiel

    Christian-Albrechts-Universität zu Kiel, Germany

    1 publications · 59 citations

    1

    h-index

1–5 of 459

Institutions

205

  1. Dana-Farber Cancer Institute

    Boston, United States

    3 h-index

    19 publications

    1.6K citations

  2. Brigham and Women's Hospital

    Boston, United States

    3 h-index

    11 publications

    737 citations

  3. Ontario Institute for Cancer Research

    Toronto, Canada

    2 h-index

    47 publications

    21.9K citations

  4. University of Southern California

    Los Angeles, United States

    2 h-index

    4 publications

    364 citations

  5. National Cancer Institute

    Bethesda, United States

    2 h-index

    2 publications

    385 citations

  6. Stanford University

    Stanford, United States

    2 h-index

    3 publications

    399 citations

  7. Neurological Surgery

    Rockville Centre, United States

    2 h-index

    5 publications

    1K citations

  8. Cancer Research UK

    London, United Kingdom

    2 h-index

    2 publications

    510 citations

1–8 of 205

Venues

  1. Nature Communications

    3 publications · 292 citations

    3

    h-index

  2. Nature Genetics

    3 publications · 1.5K citations

    3

    h-index

  3. Leukemia

    2 publications · 168 citations

    2

    h-index

  4. The Lancet Digital Health

    1 publications · 52 citations

    1

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 57 citations

    1

    h-index

1–5