Leonie G. Mikael

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Ashot S. Harutyunyan, Brian Krug, Haifeng Chen et al. · Nature Communications · 2019 · 376 citations · Full text

Stalled developmental programs at the root of pediatric brain tumors

Selin Jessa, Alexis Blanchet-Cohen, Brian Krug et al. · Nature Genetics · 2019 · 283 citations · Full text

Neuro-oncology, Pediatric Brain Tumors, Developmental Biology +10

H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas

Manav Pathania, Nicolas Jay, Nicola Maestro et al. · Cancer Cell · 2017 · 259 citations · Full text

Neuro-oncology, Developmental Biology, Trp53 Loss +10

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

Hamid Nikbakht, Eshini Panditharatna, Leonie G. Mikael et al. · Nature Communications · 2016 · 255 citations · Full text

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

Brian Krug, Nicolas Jay, Ashot S. Harutyunyan et al. · Cancer Cell · 2019 · 252 citations · Full text

Neuro-oncology, Glioma, Medicine +10