Leonie G. Mikael

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Ashot S. Harutyunyan, Brian Krug, Haifeng Chen et al. · Nature Communications · 2019 · 392 citations · Full text

Life Sciences, Genetics, Oncology +14

Stalled developmental programs at the root of pediatric brain tumors

Selin Jessa, Alexis Blanchet-Cohen, Brian Krug et al. · Nature Genetics · 2019 · 299 citations · Full text

Medicine, Oncology, Pediatrics +14

H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas

Manav Pathania, Nicolas Jay, Nicola Maestro et al. · Cancer Cell · 2017 · 270 citations · Full text

Medicine, Molecular Genetics, Oncology +13

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

Hamid Nikbakht, Eshini Panditharatna, Leonie G. Mikael et al. · Nature Communications · 2016 · 262 citations · Full text

Medicine, Cancer Biology, Oncology +15

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

Brian Krug, Nicolas Jay, Ashot S. Harutyunyan et al. · Cancer Cell · 2019 · 261 citations · Full text

Medicine, Cancer Biology, Oncology +13