Brian Krug

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Ashot S. Harutyunyan, Brian Krug, Haifeng Chen et al. · Nature Communications · 2019 · 392 citations · Full text

Life Sciences, Genetics, Oncology +14

Stalled developmental programs at the root of pediatric brain tumors

Selin Jessa, Alexis Blanchet-Cohen, Brian Krug et al. · Nature Genetics · 2019 · 299 citations · Full text

Medicine, Oncology, Pediatrics +14

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

Brian Krug, Nicolas Jay, Ashot S. Harutyunyan et al. · Cancer Cell · 2019 · 261 citations · Full text

Medicine, Cancer Biology, Oncology +13

K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas

Selin Jessa, Abdulshakour Mohammadnia, Ashot S. Harutyunyan et al. · Nature Genetics · 2022 · 158 citations · Full text

Medicine, Molecular Biology, Molecular Genetics +12

H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation

Ashot S. Harutyunyan, Haifeng Chen, Tianyuan Lu et al. · Cell Reports · 2020 · 124 citations · Full text

Life Sciences, Genetics, Oncology +16