Concepedia

Spatial Clonal Heterogeneity

Spatial Clonal Heterogeneity is a biological phenomenon characterized by the non-uniform distribution of distinct clonal populations within a spatially organized tissue or tumor microenvironment, where genetic or phenotypic diversity arises from differential clonal expansion, migration, or selection across distinct anatomical regions.

22

Publications

2.2K

Citations

181

Authors

72

Institutions

Publications per year

2017–2026

7

Parents

Publications

22

Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing

Leo Rasche, Shweta S. Chavan, Owen Stephens et al. · Nature Communications · 2017 · 419 citations · Full text

, , +16

Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells

Takeshi Okamoto, Tomoki Aoyama, Tomitaka Nakayama et al. · Biochemical and Biophysical Research Communications · 2002 · 271 citations · Full text

, , +14

Spatial genomics enables multi-modal study of clonal heterogeneity in tissues

Tongtong Zhao, Zachary Chiang, Julia W. Morriss et al. · Nature · 2021 · 270 citations · Full text

, , +14

Assessing intratumor heterogeneity and tracking longitudinal and spatial clonal evolutionary history by next-generation sequencing

Yuchao Jiang, Yu Qiu, Andy J. Minn et al. · Proceedings of the National Academy of Sciences · 2016 · 251 citations · Full text

, , +17

Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib

Lynn Quek, Muriel D. David, Alison Kennedy et al. · Nature Medicine · 2018 · 200 citations · Full text

, , +16

1–5 of 22

Authors

181

  1. AH
    Alan H. Shih

    Memorial Sloan Kettering Cancer Center, United States

    1 publications · 200 citations

    1

    h-index

  2. GL
    Guillermina Lozano

    The University of Texas MD Anderson Cancer Center, United States

    1 publications · 28 citations

    1

    h-index

  3. JM
    Jiro Matsumoto

    Keio University, Japan

    1 publications · 25 citations

    1

    h-index

  4. KH
    Katrin Horn

    Leipzig University, Germany

    1 publications · 81 citations

    1

    h-index

  5. LQ
    Lynn Quek

    University of Oxford, United Kingdom

    1 publications · 200 citations

    1

    h-index

1–5 of 181

Institutions

72

  1. The University of Texas MD Anderson Cancer Center

    Houston, United States

    3 h-index

    18 publications

    1.3K citations

  2. Inserm

    Paris, France

    2 h-index

    13 publications

    2.2K citations

  3. Institut Curie

    Paris, France

    2 h-index

    2 publications

    308 citations

  4. La Ligue Contre le Cancer

    Paris, France

    2 h-index

    12 publications

    2K citations

  5. Johns Hopkins University

    Baltimore, United States

    1 h-index

    1 publications

    55 citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    1 h-index

    1 publications

    108 citations

  7. Aichi Cancer Center

    Nagoya, Japan

    1 h-index

    1 publications

    271 citations

  8. Sorbonne Paris Cité

    Paris, France

    1 h-index

    1 publications

    108 citations

1–8 of 72

Venues

  1. Blood

    2 publications · 220 citations

    2

    h-index

  2. Nature Communications

    1 publications · 419 citations

    1

    h-index

  3. Oecologia

    1 publications · 87 citations

    1

    h-index

  4. Differentiation

    1 publications · 25 citations

    1

    h-index

  5. Ecology and Evolution

    1 publications · 35 citations

    1

    h-index

1–5